Prophylactic cranial irradiation (PCI) is being reintroduced into multimodality treatment protocols of patients with small-cell lung cancer (SCLC). The history of its use brings interesting insights into clinical evaluations of treatment strategies and design of relevant and informative trials. The critical issues of effectiveness and overall health gains of prophylactic cranial irradiation hav...

Abstract BACKGROUND: Associated with hydrocephalus, cranial irradiation, and certain chemotherapeutic agents, impairment in attention is a common feature of childhood brain tumour survivorship. Attentional processes are implicated number cognitive functions, supporting sustained selective attention, inhibition competing stimuli, management divided (multi-tasking). Acquired attentional deficit r...

background and purpose: delirium is a clinical syndrome with cognitive disorder, which occurs within a short time in the admitted patients, specially the elderly. regarding the fact that one third of the delirium incidences is preventable, applying nursing preventive measures is an issue of fundamental importance. the present study aimed to perform a systematic review over the nursing preventiv...

Cancer survivors face a variety of challenges as they cope with disease recurrence and a myriad of normal tissue complications brought on by radio- and chemotherapeutic treatment regimens. For patients subjected to cranial irradiation for the control of CNS malignancy, progressive and debilitating cognitive dysfunction remains a pressing unmet medical need. Although this problem has been recogn...

Cognitive dysfunction following cranial radiotherapy remains a significant clinical problem, particularly in patients receiving whole brain radiation and in children. This has prompted development of therapeutic strategies that spare regions involved in learning and memory, particularly the hippocampus, which contains a radiation-sensitive population of neural precursor cells that actively divi...

OBJECTIVE To evaluate the prevalence of leukoaraiosis (LA) and its correlation with vascular risk factors and the cognitive performance of elderly patients. METHOD 78 patients were randomly selected and submitted to clinic-laboratorial evaluation for vascular risk factors. Two cognitive tests were performed. All patients were submitted to cranial computerized tomography (CT), which was analyz...

objective: diabetes mellitus (dm) is a common metabolic. one of the unknown complications of dm is cognitive disorders. different types of cognitive impairment caused by dm may affect the quality of life, self-management of diabetes, and glycosylated hemoglobin. this study aimed to determine the prevalence of cognitive impairment and its relationship with glycosylated hemoglobin (hba1c), diabet...