The collapse temperature (Tc) and the glass transition temperature of freeze-concentrated solutions (Tg') as well as the crystallization behavior of excipients are important physicochemical characteristics which guide the cycle development in freeze-drying. The most frequently used methods to determine these values are differential scanning calorimetry (DSC) and freeze-drying microscopy (FDM). ...

By using single molecule fluorescence resonance energy transfer (smFRET), the equilibrium denaturation of staphylococcal nuclease (SNase) induced by guanidinium hydrochloride (GdmCl) has been investigated. We have characterized the collapse of the denatured chain and its relation to structure formation. Two mutants, K28C/H124C and K28C/K97C, were constructed and labeled for monitoring the behav...

The 10.6 km long Sabzkuh water conveyance tunnel is currently under construction in High Zagros structural zone, located in western Iran, has used conventional (in section T1) and mechanized (in section T2) methods. The section T1 of the tunnel driven through alluvial geological units with great complexity in an area high potential for sliding and water-bearing fault which has made the excavati...

It is difficult to monitor the collapse position of a gas extraction borehole in coal seam. In order solve this problem, fiber-optic grating monitoring technology was proposed. Five kinds arrangements (0°, 45°, 90°, 135°, 180°) were examined simulate hole collapse. The relationship model between center wavelength offset and amount collapsed flow constructed obtain distribution curve quality alo...

Current collapse in AlGaN/GaN HFETs is investigated at low temperatures using a transient current monitoring technique. The carrier trapping and detrapping mechanisms are studied, and two distinct relaxation mechanisms are observed. They are associated to the presence of two close deep energy levels in the bandgap.

Although several studies have investigated the effect of degradation on the behavior of structures, investigations on collapse margin ratios are rare in the literature. In this study, the effect of strength and stiffness degradation on collapse capacity of steel moment frames is investigated. The aim is to determine margin of safety against collapse using a probabilistic approach. For this reas...

The answer may be yes. A discrete model of energy-conserved wavefunction collapse is proposed. It is shown that the model is consistent with existing experiments and our macroscopic experience.