نتایج جستجو برای: colon delivery
تعداد نتایج: 278536 فیلتر نتایج به سال:
Piceatannol (PCT), an anti-colitic natural product, undergoes extensive Phase II hepatic metabolism, resulting in very low bioavailability. We investigated whether colon-targeted delivery of PCT could enhance anti-colitic effects and how therapeutic enhancement occurred at the molecular level. Molecular effects of PCT were examined in human colon carcinoma cells and inflamed colons. The anti-co...
Fabrication, Physicochemical Characterization and Evaluation of In vitro Anticancer Efficacy a Novel pH Sensitive Polymeric Nanoparticles for Efficient Delivery Hydrophobic Drug against Colon CancerManikandan Mahalingam, Kannan Krishnamoorthy
Colonic targeting has gained increasing interest over the past years. A considerable number of patents and publications dealing with the colon specific drug delivery system indicate a growing focus of research activities in this field, not just for the delivery of the drugs for the treatment of the local pathologies associated with the colon but also for its potential for the systemic delivery ...
The colon is a site where both local and systemic delivery of drugs can take place. Local delivery allows topical treatment of inflammatory bowel disease. However, treatment can be made effective if the drugs can be targeted directly into the colon, thereby reducing the systemic side effects. This review, mainly compares the primary approaches for CDDS (Colon Specific Drug Delivery) namely prod...
Single pH-dependent drug delivery systems have been widely used for colon-targeted delivery, but their efficiency is often hampered by the variation in gut pH. To overcome the limitation of single pH-dependent delivery systems, in this study, we developed and evaluated the therapeutic potential of budesonide-loaded dual pH/time-dependent nanoparticles (NPs) for the treatment of colitis. Eudragi...
Colonic drug delivery has gained remarkable importance for the delivery of the drugs for the treatment of local diseases associated with the colon. To achieve successful colonic delivery, colon targeting is of prime importance. Various natural therapies, available for the treatment of colonic diseases like ulcerative colitis, Intestinal bowel syndrome, colon cancer, diverticulitis, etc., are ba...
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