CEACAM1a glycoproteins are members of the immunoglobulin (Ig) superfamily and the carcinoembryonic antigen family. Isoforms expressing either two or four alternatively spliced Ig-like domains in mice have been found in a number of epithelial, endothelial, or hematopoietic tissues. CEACAM1a functions as an intercellular adhesion molecule, an angiogenic factor, and a tumor cell growth inhibitor. ...

Ceacam1a / Mice Are Completely Resistant to Infection by Murine Coronavirus Mouse Hepatitis Virus A59 Erin Hemmila, Claire Turbide, Melanie Olson, Serge Jothy, Kathryn V. Holmes,† and Nicole Beauchemin*† Department of Microbiology, University of Colorado Health Sciences Center, Denver, Colorado, and McGill Cancer Centre and Departments of Biochemistry, Medicine, and Oncology, McGill University,...

The development of drug resistance by tumor cells is a major obstacle to the cure of human malignancy. Cyclosporin A (CsA) completely reverses primary resistance to vincristine and cross resistance to daunorubicin in a pleiotropic drug-resistant subline of human T cell acute lymphatic leukemia. This subline is over 50-fold resistant to vincristine and fivefold resistant to daunorubicin. CsA has...

Antiestrogens represent the first line of therapy in the treatment of estrogen receptor-positive (ER+) breast cancer patients. Unfortunately, up to 40% of patients develop resistance associated with progression and frequently die for metastatic breast cancer. The molecular events leading to pharmacological resistance are not completely understood. We attempted to verify in an experimental model...

Nineteen safflower genotypes (Carthamus tinctorius L.) that originated from different geographical regions were screening for their response to infection with Macrophomina phaseolina, the charcoal rot pathogen at the research farm of Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran, in 2005. The plants were evaluated for length and width of necrotic lesion at the e...

For infections with antibiotic-susceptible strains of Pseudomonas aeruginosa, most studies have suggested that combination therapy, usually with a beta -lactam antibiotic plus an aminoglycoside, is preferable for patients with bacteremia and neutropenia. Against infections with Pseudomonas aeruginosa or Acinetobacter baumannii isolates that are resistant to all antibiotics except the polymyxins...