OBJECTIVE To evaluate whether adding comorbid conditions to a risk model can help predict in-hospital outcome and long-term mortality after percutaneous coronary intervention (PCI). DESIGN Retrospective chart review SETTING Academic medical centre. PATIENTS 7659 patients who had 9032 PCIs. INTERVENTIONS PCI performed at Mayo Clinic between 1 January 1999 and 30 June 2004. MAIN OUTCOME...

Medical case reports (MCRs) have been undervalued in the literature to date. It seems that while case series emphasize what is probable, case reports describe what is possible and what can go wrong. MCRs transfer medical knowledge and act as educational tools. We outline evolving aspects of the MCR in current practice.

Mesophotic coral reefs (MCRs) are an understudied continuum of shallow coral reef communities at depths of 30 to 150 m. These reefs are subject to gradients of light and nutrients that results in changes to the community structure and function with increased depth. The upper mesophotic reef is comprised of many of the same species that are found in shallow coral reef systems. However, the lower...

The evolution of the melanocortin receptors (MCRs) is linked to the evolution of adrenocorticotrophic hormone (ACTH), the melanocyte-stimulating hormones (MSHs), and their common precursor pro-opiomelanocortin (POMC). The origin of the MCRs and POMC appears to be grounded in the early radiation of the ancestral protochordates. During the genome duplications that have occurred during the evoluti...

The melanocortin receptors (MCRs) are a gene family in the rhodopsin class of G protein-coupled receptors. Based on the analysis of several metazoan genome databases it appears that the MCRs are only found in chordates. The presence of five genes in the family (i.e., mc1r, mc2r, mc3r, mc4r, mc5r) in representatives of the tetrapods indicates that the gene family is the result of two genome dupl...

Highly functionalized multisubstituted 1,4-dihydropyridines 5 have been concisely synthesized in moderate to good yields via L-proline-catalyzed one-pot multicomponent reactions (MCRs) of alkynoates or alkynones 1, amines 2, beta-dicarbonyl compounds 3 and aldehydes 4 under mild conditions. The MCR process involves hydroamination/Knoevenagel condensation/Michael-type addition/intramolecular cyc...

Abstract In this study, we evaluated the performance of nano-?-Fe 2 O 3 –SO H catalyst in Biginelli reaction and synthesized 3,4-dihydropyrimidine-2-(1 )-ones. This was carried out under solvent-free ultrasonic irradiation conditions belonged to one-pot multicomponent reactions (MCRs) with an adopted aromatic aldehyde, ethyl acetoacetate, urea as starting materials for beginning reaction. The w...

Diesel Engine adalah motor bakar pembakaran dalam (Internal Combustion Engine), yang bahan bakarnya disemprotkan ke ruang silinder pada waktu piston berada di titik mati atas (TMA). Penelitian ini bertujuan untuk mengetahui permasalahan terjadi kepala silinder, khususnya mesin QSK 50 MCRS, sehingga perawatan lebih baik, guna mengoptimalkan pengoperasian proses industri. dilakukan mendapatkan da...

BACKGROUND Small polyfunctionalized heterocyclic compounds play important roles in the drug discovery process and in the isolation and structural identification of biological macromolecules. It is expected that ready access to diverse sets of heterocycles can not only help improving the known biological and pharmacokinetic properties of drugs, but also assist the discovery of molecules that exh...