The Nanostructured Lipid Carriers (NLCs) was formulated with the aim to improve aqueous solubility and thus ultimately oral bioavailability of Axitinib. Axitinib loaded NLCs were using Compritol ATO 888 as solid-lipid, Oleic acid liquid-lipid Tween 80 surfactant by High-Pressure Homogenization technique. A full 23 factorial design utilized study effect independent parameters, solid-lipid ratio ...

Solid lipid nanoparticles of atovaquone (ATQ-SLN) were prepared by high shearhomogenization method using tripalmitin, trilaurin, and Compritol 888 ATO as the lipidmatrices and Phospholipon 90H, Tween 80, and poloxamer 188 as the surfactants. Optimizationof the formulations was conducted using 6 sets of 24 full-factorial design based on fourindependent variables that were the number of homogeniz...

Solid lipid nanoparticles of atovaquone (ATQ-SLN) were prepared by high shearhomogenization method using tripalmitin, trilaurin, and Compritol 888 ATO as the lipidmatrices and Phospholipon 90H, Tween 80, and poloxamer 188 as the surfactants. Optimizationof the formulations was conducted using 6 sets of 24 full-factorial design based on fourindependent variables that were the number of homogeniz...

The objective of research was to explore the suitability of lipids like compritol 888 ATO and stearic acid as release retardant to develop sustained release (SR) tablets. The SR micromatrices of lipid (s) and glipizide were prepared (LM1- LM6) as intermediate product by fusion method and assessed for various pharmacotechnical properties. Micromatrices were formulated as SR tablets (F1-F6) by di...

Berberine (BBR) possesses several biological activities in humans, but the poor water solubility and low oral bioavailability preclude its pharmacological use. To overcome these limitations, formulations have been prepared including encapsulation, micro- nano-emulsion. The aim of this study was to develop a nanoemulsion delivery system BBR evaluate membrane permeability using Caco-2 cell model....

The objective of the present study was to establish the individual and combined chemopreventive potential of a widely used non-steroidal anti-inflammatory drug, ibuprofen (IBU), encapsulated in solid lipid nanoparticles (SLNs) for the chemoprevention of pancreatic cancer. The IBU SLNs were optimized using various lipids (Stearic acid, Compritol 888 ATO and Tripalmitin) and surfactants (Poloxame...

A new generation of nanostructured lipid carriers (NLCs) consisting of a lipid matrix with a special nanostructure has been developed. This nanostructure improves drug loading and firmly incorporates the drug during storage. Surfactants play important roles in the formation and characterization of nanostructured lipid carriers. In order to investigate the influence of surfactants on properties ...

BACKGROUND Type I hypersensitivity is an allergic reaction characterized by the overactivity of the immune system provoked by normally harmless substances. Glucocorticoids, anti-histamines, or mast cell stabilizers are the choices of treatment for type I hypersensitivity. Even though these drugs have the anti-allergic effect, they can have several side effects in prolong use. Cedrol is the main...

Objective: Vitamin E acetate has antioxidant activity that can prevent premature aging of the skin, but it is highly lipophilic (log p±12.2) and potentially degraded. To overcome permeability stability problems, vitamin needs to be developed in Nanostructured Lipid Carrier (NLC), a nano-delivery system based on solid lipid liquid stabilized by surfactants as colloidal system.
 Methods: The...

The article by Hughes et al. [1] from the Pediatric AIDS Clinical Trials Group describing a randomized comparison of daily administration of trimethoprim-sulfamethoxazole (TMP-SMZ) and ato-vaquone-azithromycin brings into focus a number of interesting issues related to HIV infections worldwide, as well as the daily use of prophylactic antimicrobials in general. The trial was halted early, befor...