Congenital gingival granular cell tumor is a rare benign lesion of uncertain origin, which has been found only in newborn infants. This article describes one such case. Our immunohistochemical study employing antibodies against S-100 protein, epithelial membrane antigen, carcinoembryonic antigen, wide-spectrum keratin, desmin and vimentin yielded data supporting the theory of a mesenchymal cell...

A congenital epulis is a rare benign jaw tumor of neonate and is also known as “congenital gingival granular cell tumor”. The Greek word ‘‘epulis’’ means ‘‘swelling of the gingiva’’. It was first described in 1871 by Neumann; hence the alternative name is Neumann’s Tumor [1]. It usually presents at birth with an obvious mass arising from the gingival mucosa of the maxilla or mandible. It common...

Congenital granular cell tumor is a rare tumor which arises from alveolus. We describe a case diagnosed and treated in a neonate. Twenty-eight cases have been reported in Japan, with a male:female ratio of 1:6.3. The location of the tumor was the mandible in 13, the maxilla in 15 and multiple in 1. The left side incisor region was the most common site.

Congenital granular cell tumor (CGCT) is a rare benign neoplastic growth of the anterior maxilla of neonates. The tissue origin of this lesion whether it is from neural or muscular; is still debatable although many immunohisto chemical markers studies have been documented. We present a case report of a female neonate with a large CGCT along with a brief review of literature.

Ceren Yıldırım, Tamer Zerener , Metin Şençimen , Özlem Martı Akgün , Hasan Ayberk Altuğ , Ali Fuat ÇİÇEK 3 1 Dept. of Pediatric Dentistry, University of Health Sciences, Gulhane Health Sciences Institute, Ankara, Turkey. 2 Dept. of Maxillofacial Surgery, University of Health Sciences, Gulhane Health Sciences Institute, Ankara, Turkey. 3 Dept. of Pathology, Gulhane Education and Research Hospita...

A 4-month-old infant presented with asymptomatic soft nodules on his right forearm, which had developed since birth. On the suspicion of nevus lipomatosus superficialis (NLS), biopsy was performed. Histopathologic findings showed monomorphic polygonal cells with abundant granular cytoplasm. Immunohistochemical stains for CD68 and vimentin were strongly positive, but were negative for S-100 prot...

Congenital granular cell tumor (CGCT), or congenital epulis, is a very uncommon benign soft tissue lesion that usually arises from the alveolar mucosa of neonates and may cause respiratory and feeding problems. We report a case of a 3-day-old female newborn, who presented an intraoral tumor mass which was protruding from her mouth, and compromising feeding. Under general anesthesia, the lesion ...

INTRODUCTION Congenital oral granular cell tumour of the newborn is an uncommon benign tumour of uncertain origin. The typical clinical appearance is of a single nodule occurring on the anterior maxillary ridge. In 10% of cases there are multiple lesions. The occurrence of congenital epulis in non-Caucasians is rare. CASE PRESENTATION Two firm pedunculated nodular lesions were noticed in the ...

Congenital granular cell lesion (CGCL) is a rare non-neoplastic lesion found in newborns also known as Neumann's tumor. This benign lesion occurs predominantly in females mostly as a single mass. The histogenesis and natural history of the lesion remains obscure. It arises from the mucosa of the gingiva, either from the maxillary or mandibular alveolar ridge. The lesion is more common in the ma...