Background Dextrocardia is a malposition of the heart defined as the right-sided development of the heart. It can increase the likelihood of congenital heart defects or diseases (CHD) and the risk of related morbidities and mortalities. We aimed to determine the frequency of CHDs among Dextrocardia patients. Materials and Methods In a retrospective cross-sectional study the records of patients ...

1920x1200 abstract: background: down syndrome is the most common chromosomal abnormality due to 21 trisomy that usually is accompany with congenital heart diseases. about fifty present of children with down syndrome have heart defects. this study was designed for the aim of abundance percents of septal heart defects in children with down syndrome at imam reza and imam ali hospitals in kermansha...

Holt-Oram syndrome is an autosomal dominant disorder, characterised by skeletal abnormalities of the upper limb associated with congenital heart defect, mainly atrial and ventricular septal defects. Skeletal defects exclusively affect the upper limbs in the preaxial radial ray distribution and are bilateral and asymmetrical. They range from clinodactyly, absent or digitalised thumb, hypoplastic...

The 22q11.2 microdeletion syndrome is one of the common microdeletion syndromes seen among children with Congenital Heart Defects. Population based studies have shown the prevalence of 22q11.2 microdeletion syndrome range from 1 in 4000 to 1 in 6000 live births.1,2 Over 80% of children with 22q11.2 microdeletion syndrome have Congenital Heart Defects.1,3,4 Diagnosis of 22q11.2 microdeletion syn...

Objective To evaluate whether the association between maternal periconceptional use of selective serotonin reuptake inhibitors (SSRIs) and increased risk of congenital heart defects in offspring is modified by maternal or infant genetic variants in folate, homocysteine, or transsulfuration pathways.Design Population based study. DNA from mothers, fathers, and infants was genotyped with an Illum...

OBJECTIVE To analyze the frequency and prevalence of congenital heart defects in a tertiary care center for children with heart diseases. METHODS We carried out an epidemiological assessment of the first medical visit of 4,538 children in a pediatric hospital from January 1995 to December 1997. All patients with congenital heart defects had their diagnoses confirmed at least on echocardiograp...

IMPORTANCE The risk of congenital heart defects in infants of women who had preeclampsia during pregnancy is poorly understood, despite shared angiogenic pathways in both conditions. OBJECTIVE To determine the prevalence of congenital heart defects in offspring of women with preeclampsia. DESIGN, SETTING, AND PARTICIPANTS Population-level analysis of live births before discharge, 1989-2012,...

Congenital heart defects comprise the most common form of major birth defects, affecting 0.7% of all newborn infants. Jacobsen syndrome (11q-) is a rare chromosomal disorder caused by deletions in distal 11q. We have previously determined that a wide spectrum of the most common congenital heart defects occur in 11q-, including an unprecedented high frequency of hypoplastic left heart syndrome (...