Objectives: Vancomycin use for neonatal coagulase-negative staphylococci (CoNS) sepsis is based on a high CoNS carriage rate of mecA, encoding penicillin-binding protein (PBP)-2a, with low affinity for, and associated with resistance to, b-lactam antibiotics. The relationship between mecA gene carriage, phenotypic expression of the gene by PBP-2a production and in vitro resistance to the b-lact...

BACKGROUND Coagulase-negative staphylococci (CoNS) are one of the most frequent causative agents of neonatal nosocomial infections, especially in premature and low-weight newborns. Risk factors for infection include extracellular polysaccharide production and consequent biofilm formation that permit adhesion to the smooth surface of catheters and other medical devices. The objective of this stu...

Established preoperative antibiotic prophylaxis in cardiac surgery is ineffective against methicillin-resistant coagulase-negative staphylococci (CoNS). This case-control study aimed to determine factors predicting deep sternal wound infections due to methicillin-resistant CoNS. All cardiac surgery patients undergoing sternotomy between June 2009 and March 2013 prospectively documented in a Swi...

BACKGROUND Coagulase negative staphylococci (CoNS) and Listeria monocytogenes have important roles in pathogenesis of various genital tract infections and fatal foetomaternal infections, respectively. The aim of our study was to investigate the inhibitory effects of two novel bacteriocins on biofilms of CoNS and L. monocytogenes genital isolates. METHODS The effects of licheniocin 50.2 from B...

BACKGROUND Worldwide increase in antibiotic resistance has become one of the major problems. Optimal and rationale use of antibiotic is important to prevent resistance against most of the bacteria including Coagulase-negative Staphylococci (CoNS), which has now been recognized as an important pathogen for nosocomial infections. This study was carried out to determine efficacy of vancomycin and ...

BACKGROUND Coagulase-negative staphylococci (CoNS) are opportunistic pathogens. Methicillin resistance is common in CoNS and may play an important role as reservoir of staphylococcal cassette chromosome mec (SCCmec) for Staphylococcus aureus. OBJECTIVES The aim of this study was to determine molecular characteristics of nasal carriage of methicillin-resistant coagulase negative staphylococci ...

BACKGROUND Neonatal mortality remains high in sub-Saharan Africa, and a third of deaths are estimated to result from infection. While coagulase-negative staphylococci (CoNS) are leading neonatal pathogens in resource-rich settings, their role, and the need for early anti-Staphylococcal treatment in empiric antibiotic guidelines, is unknown in sub-Saharan Africa. METHODS We examined systematic...

Distinguishing true coagulase-negative staphylococci bacteremia from contamination remains a challenge. We conducted a retrospective analysis of 183 patients with methicillin-resistant coagulase-negative staphylococci (MR-CoNS)-positive and methicillin-resistant Staphylococcus aureus-positive cultures obtained from sterile sites such as blood, synovial fluid, ascitic fluid, and cerebrospinal fl...

The study was aimed at characterizing the different Coagulasenegative staphylococci (CoNS) isolated from chronic skin ulcer out-patients attending four different hospitals in Kaduna State, Nigeria. A total of 292 swab samples were collected from January 2012 to January 2013. The samples were cultured using Chocolate and Blood agar media. Phenotypic characterization of the CoNS revealed the pres...

23 strains of rhizobia, from 14 leguminous species, were evaluated on a Thai cultivar of Voandzeia* in Leonard jar trials. The symbiosis ranged from completely ineffective through moderate effectiveness to fully effective. Bradyrhizobium sp. TAL 169, isolated from Vigna unguiculata, ranked most-effective; the widespectrum Bradyrhizobium strain CB 756 was ineffective. In a cultivar x Bradyrhizob...