BACKGROUND Various methods are used to induce maximal hyperemia for physiologic studies, but the feasibility and efficacy of continuous intracoronary (IC) infusion of adenosine for measurement of fractional flow reserve (FFR) has not been well-defined. METHODS AND RESULTS Patients with intermediate coronary artery stenosis were consecutively enrolled. In the phase I study, FFR was measured af...

background: early warning of potential damage to spinal cord during major spinal surgery is highly desirable to prevent post-operative neurological deficits. wake-up test is a simple, safe and reliable method of recognition of such a complication, and has been extensively used in many spinal surgical units. the present study is evaluating the remifentanil, propofol versus alfentanil, propofol a...

STUDY OBJECTIVE To compare continuous versus intermittent administration of piperacillin-tazobactam with regard to clinical, microbiologic, and economic outcomes. DESIGN Prospective, open-label controlled study SETTING Community teaching hospital. PATIENTS Ninety-eight hospitalized patients prescribed piperacillin-tazobactam. INTERVENTION Substitutions were implemented so that 47 patien...

A patient suffering from severe symptomatic primary pulmonary hypertension (PPH) underwent long-term intravenous prostacyclin therapy; the first time for such treatment in Japan. A 26-year-old male had experienced gradually progressive dyspnea for about one year. Despite conventional therapy he suffered repeated syncopal attacks. However, after receiving a permanent central venous access device...