the classical triad of mccune-albright syndrome (mas) consists of polyostotic fibrous dysplasia (fd), skin hyperpigmentation (café-au-lait spots), and endocrine dysfunction, frequently seen in females as precocious puberty. etiology is genetically based and is explained by mosaicism of activating somatic mutations of the alpha-subunit of gs protein. clinical presentation is varied and is depend...

A recent study has provided evidence that the use of contralateral prophylactic mastectomy (CPM) is increasing.[1] Over the 5-year period from 1998 to 2003, the CPM rate doubled. Prior studies have shown that the surgical procedures chosen by patients are most commonly influenced by physician and surgeon recommendation. This has been observed in the choice of CPM as well.[2] The data strongly s...

Consideration of the well-known very stable icosahedral B12H12(2-) as a three-dimensional analogue of benzene was extended by the recent synthesis of the biicosahedral B21H18(-) as a three-dimensional analogue of naphthalene. The preferred structures of metallaboranes derived from B21H18(-) have now been examined by density functional theory. The isoelectronic species CpNiB20H17 and CpCoCB19H17...

BACKGROUND Rates of contralateral risk-reducing mastectomy (CRRM) are rising, despite a decreasing global incidence of contralateral breast cancer. Reasons for requesting this procedure are complex, and we have previously shown a variable practice amongst breast and plastic surgeons in England. We propose a protocol, based on a published systematic review, a national UK survey and the Mancheste...

The reasons for the high risk of contralateral breast cancer are not understood, although polygenic mechanisms have been suggested to be involved. The nationwide Swedish Family-Cancer Database was used to examine the interaction of the risks for contralateral and familial cancer. Relative risks were separately determined for contralateral and familial breast cancers, and these were tested for a...

the effect of chronic inflammation induced by complete freund's adjuvant (cfa) on anterior blood vessels of knee joint and its diameter was studied. blood flow changes in response to phenylephrine (αl-adrenoceptor agonist) in cfa-treated and contralateral knee joints were observed over a 40-day period, using laser doppler flowmetery (ldf) technique. unilateral injection of cfa (0.2 ml) inc...

Objectives: MRI is the most sensitive modality for local staging of breast cancer. Herceptin receptor over-expression seen in 15% - 30% tumours, and associated with increased aggression, poorer prognosis, higher grade at diagnosis lymphatic dissemination. This study aimed evaluating role positive vs negative tumours. Methods: 193 pre-operative MRIs were performed 2021 162 Her-2 37 Recall rates ...