randomization is an essential component of sound clinical trials which prevents selection biases and helps in blinding the allocations. randomization is a process by which subsequent subjects enrolled into trial groups only by chance which is essentially eliminates selection biases. a serious consequence of randomization is severe imbalance among treatment groups with respect to some prognostic...

background: tocotrienols have been shown to improve glycemic control and redox balance in an animal study, but their effects on patients with diabetes are unknown. the study aimed to investigate whether tocotrienols improves glycemic control, insulin sensitivity,and oxidative stress in individuals with type 2 diabetes mellitus (t2dm). materials and methods: this study was a double-blinded,place...

the aim of this randomized controlled clinical trial was to investigate the effect of a new iranian toothpaste and a commercially available toothpaste containing desensitizing agent (5% potassium nitrate) on dentine hypersensitivity in a 24-week study.fifty healthy volunteers, who had at least two sensitive root surfaces, completed the study period. the participants were randomly given one of t...

background: massive ischemic stroke causes significant mortality and morbidity in stroke patients. the main treatments for massive ischemic stroke are recombinant tissue plasminogen activator (rtpa), craniotomy, and endovascular interventions. due to destructive  effects  of   bradykinin  on  the  nervous system in ischemic stroke, it seems reasonable that using noscapine as a bradykinin antago...

introduction: the prevalence of hypertension in patients with type 2 diabetes (t2d) is approximately twice as much as healthy people. this study was designed to determine the effect of l-arginine supplementation on blood pressure in patients with t2d. methods: in a double-blind randomized clinical trial, 75 t2d were randomly divided into three groups (3 g/d and 6 g/d of l-arginine and placebo) ...

asparagus racemosus willd. has repeatedly been mentioned as a galactogogue in ayurvedic literature and has been confirmed through animal experiments as well. this randomized double-blind clinical trial evaluates its galactogogue effect in 60 lactating mothers by measurement of changes in their prolactin hormone level during the study. several secondary parameters namely mothers’ weight, babies’...

introduction:   palmoplantar psoriasis could hardly be differentiated from chronic tylotic eczema both clinically and histologically. the most commonly used therapeutic options for palmoplantar psoriasis are long-term therapy with topical corticosteroids and local puva. frequently, it is a recalcitrant disease. we investigated the efficacy and tolerability of the combination of topical calcipot...

background menopause is a period of women’s lives with changes and symptoms that affect their work, sleep and quality of life. therefore, it is important to overcome these symptoms. objectives the aim of the present study was to compare the effects of calci soya balance and vitagnus on menopausal symptoms. patients and methods this double-blinded controlled trial study was performed in public h...