Controlled release (CR) formulations have generally been considered as follow-ons to conventional immediate release formulations to manage the life cycle of a product. Although significant opportunities exist to use CR as an enabling technology for certain exploratory drug candidates, they have not been fully exploited. However, progress made in assessing CR feasibility based on the physicochem...

ficial outdoor pond to maintain constant temperature. Technical grade nonylphenol (Sigma, Aldrich) was applied using a controlled release technique (Pfister et al. 1999) to maintain different levels of nonylphenol concentrations (9 to 112 gg/L) in the water column. The microcosms were set up in May. The application period started in June and lasted 45 days, followed by a period without applicat...

We have performed a comparison of magnetoresistance and structure of epitaxial and textured Fe/Cr superlattices grown by molecular-beam epitaxy ~MBE! and magnetron sputtering with either ~110! and ~100! orientations on a variety of substrates. MBE samples grown along the ~100! orientation, exhibit narrower rocking curves ~mosaic spread! and lower saturation resistivities than sputtered samples....

this study was performed to design bilayer regioselective floating tablets of atenolol and lovastatin to give immediate release of lovastatin and sustained release of atenolol. bilayer floating tablets comprised two layers, i.e immediate release and controlled release layers. the immediate release layer comprised sodium starch glycollate as a super disintegrant and the sustained release layer c...

A quantitative theory of attosecond pulse generation in relativistically driven overdense plasma slabs is presented based on an explicit analysis of synchrotron-type electron trajectories. The subcycle, field-controlled release, and subsequent nanometer-scale acceleration of relativistic electron bunches under the combined action of the laser and ionic potentials give rise to coherent radiation...

Hyperbranched polymers based on a polyether and polyester have been modified and used as macromolecular ligands for the anticancer drug cisplatin, giving controlled release of the drug over 7 days.

We report a novel strategy to construct temperature-responsive nanocarriers for controlled release based on mesoporous silica and reversible single-stranded DNA valves.