نتایج جستجو برای: core e1e2
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Hepatitis C virus (HCV) is world-wide a major cause of liver related morbidity and mortality. No vaccine is available to prevent HCV infection. To design an effective vaccine, understanding immunity against HCV is necessary. The memory B cell repertoire was characterized from an intravenous drug user who spontaneously cleared HCV infection 25 years ago. CD27+IgG+ memory B cells were immortalize...
A Smarandachely k-signed graph (Smarandachely k-marked graph) is an ordered pair S = (G,σ) (S = (G,μ)) where G = (V, E) is a graph called underlying graph of S and σ : E → (e1, e2, ..., ek) (μ : V → (e1, e2, ..., ek)) is a function, where each ei ∈ {+,−}. Particularly, a Smarandachely 2-signed graph or Smarandachely 2-marked graph is called abbreviated a signed graph or a marked graph. Given a ...
Hepatitis C virus (HCV) envelope proteins E1 and E2 play an essential role in virus entry. However, the fusion mechanisms of HCV remain largely unclear, hampering the development of efficient fusion inhibitors. Here, we developed two cell-based membrane fusion models that allow for screening a peptide library covering the full-length E1 and E2 amino acid sequences. A peptide from the E2 stem do...
The basic objectives and procedures for successful crossbreeding of beef cattle were considered, with special reference to the levels of realized hybrid vigor that might be anticipated for different crossbreeding programs involving the American Brahman (Z1) and European (Ej) breeds. Intralocus heterozygosis levels with respect to breed origin of genes (breed heterozygosis) were computed for var...
Structure-function analysis of the hepatitis C virus (HCV) envelope glycoproteins, E1 and E2, has been difficult due to the unavailability of HCV virions. Truncated soluble forms of E2 have been used as models to study virus interaction with the putative HCV receptor CD81, but they may not fully mimic E2 structures on the virion. Here, we compared the CD81-binding characteristics of truncated E...
Hepatitis C virus (HCV) infects ∼2% of the world's population. It is estimated that there are more than 500,000 new infections annually in Egypt, the country with the highest HCV prevalence. An effective vaccine would help control this expanding global health burden. HCV is highly variable, and an effective vaccine should target conserved T- and B-cell epitopes of the virus. Conserved B-cell ep...
Four of these classes were separately shown previously to be enumerated by this sequence, while the five others are new. In chronological order of publication, see [1, Lemma 10] for T2, [4, Example 6.4] for T9, [9, Theorems 3.4 and 3.5] for T4, and [3, Section 3.3] for T8. The same sequence also enumerates unimodal inversion sequences [8]. An inversion sequence (subexcedant sequence, a reversal...
UNLABELLED In hepatitis C virus (HCV)-infected cells, the envelope glycoproteins E1 and E2 assemble as a heterodimer. To investigate potential changes in the oligomerization of virion-associated envelope proteins, we performed SDS-PAGE under reducing conditions but without thermal denaturation. This revealed the presence of SDS-resistant trimers of E1 in the context of cell-cultured HCV (HCVcc)...
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