PURPOSE To clarify the usefulness of multilayer amniotic membrane transplantation in an unusual case of calcareous corneal degeneration in a patient with graft-versus-host disease. METHODS A 20-year-old Caucasian woman had bilateral calcareous corneal degeneration of one year of evolution, secondary to graft-versus-host disease. Treatment for both eyes with topical steroids and antibiotic oin...

PURPOSE To evaluate the effects of dry eye on ocular surface protease activity and sight threatening corneal complications following ocular surface chemical injury. METHODS C57BL/6 mice were subjected to unilateral alkali burn (AB) with or without concomitant dry eye for 2 or 5 days. Mice were observed daily for appearance of corneal perforation. Whole corneas were harvested and lysed for RNA...

PURPOSE To study the predisposing conditions, treatments, and visual outcomes of nontraumatic corneal perforations. METHODS A retrospective chart review was conducted of all nontraumatic corneal perforations seen between January 1992 and December 1998, with > or = 3 months of follow-up, at the Cornea Service Wills Eye Hospital. RESULTS A total of 40 nontraumatic corneal perforations was ana...

Our goal is to prove that during corneal perforation, when it larger than 3 mm, we should not rush perform keratoplasty (cornea transplant). First, do our best and fight the end preserve a patient's own cornea, in which amniotic membrane will help us. In 15 patients with where size of perforation exceeded 3-4 surgical treatment was performed piece applied cornea. 14 out 15, their cornea moderat...

IMPORTANCE The combined use of autologous fibrin membrane and the eye platelet-rich plasma (E-PRP) clot could be considered as a new surgical alternative for the closure of corneal perforations. OBJECTIVE To evaluate the use of autologous solid platelet-rich plasma in combination with an autologous fibrin membrane as a surgical alternative for wound closure in perforated corneal ulcers. DES...

Bullous Keratopathy, a severe edema of the corneal stroma and epithelium with a characteristic bulla formation on the corneal surface, is a rare opthalmological emergency in cats. Rapidly progressive and uncontrollable by medical means, this condition will result in corneal perforation hours after initial presentation if left unattended. Its pathophysiology and treatment options are reviewed in...

This case report is about a rare disease with unusual presentation. Failure to recognise atypical presentation may lead to error in managing the patient and cause disastrous complications. Here we highlight a case of Terrien Marginal Degeneration in both eyes with atypical presentation; namely pseudopterygium. A 22 year old man was referred to our centre for iatrogenic right eye corneal perfora...

Bacterial keratitis is a serious ocular infectious disease that can threaten vision. The disease generally progresses rapidly and can lead to corneal scar, stromal abscess formation, perforation, and dissemination to adjacent tissues if not treated properly. Recent studies showed that corneal collagen crosslinking (CCC) using ultraviolet-A/riboflavin is effective in the treatment of bacterial k...