The haemodynamic and myocardial metabolic effects of adding 50 per cent nitrous oxide to 0.5 per cent halothane were studied in 13 patients, before the surgical incision for coronary artery vein grafts. Cardiac output and coronary sinus blood flow were determined by thermodilution, along with haemodynamic measurements. Measurements 15 minutes after addition of nitrous oxide revealed a significa...

The derivation of coronary sinus flow during increased pulmonary and right ventricular pressures was resubmitted to experimental study. The primary reduction and subsequent augmentation in coronary flow following pulmonary artery constriction and the persistence of a greater flow after release preclude the concept of a variable contribution via thebesian channels from the right ventricular cavi...

• Until recently it was widely believed that the therapeutic value of nitroglycerin in angina pectoris depended on the capacity of this drug to increase coronary flow by vasodilatation. While brief increase of coronary flow may follow on the administration of nitrates in the dog, this effect is very shortlived" and in man with ischemic heart disease, there is no evidence that therapeutic doses ...

The effects of soman (pinacolyl methylphosphonofluoridate) on coronary blood flow, the electrocardiogram, and cardiac function were measured in alpha-chloralose-anesthetized swine. Coronary blood flow (CBF), mean arterial blood pressure (MAP), peak systolic left ventricular pressure (IVP), maximum rate of left ventricular pressure development (dP/dtmax), cardiac output, and the ECG were monitor...

Coronary artery ectasia is a rare angiographical finding, and it accounts for less than 5% of all coronary angiograms. We report a case of a 55-year-old male patient who presented with fatigue and exertional chest pain. Paraclinical tests revealed cardiac ischemia and sinus node dysfunction, as well as coronary artery ectasia without significant coronary stenosis. Factors involved in cardiac is...

The effects of sodium nitroprusside alone and in combination with phenylephrine were studied at the time of cardiac catheterisation in 10 patients with normal left ventricular function. Nitroprusside was infused to reduce mean arterial pressure in 5 patients with the heart rate free (group 1) and in 5 with the heart rate fixed by atrial pacing (group 2). In group 1 nitroprusside increased heart...

The effects of metabolic coronary vasodilation on transcapillary exchange in the heart were examined in anesthetized dogs by use of the multiple indicator dilution technique. Animals were studied under basal conditions and during coronary sinus pacing. To obviate adrenal medullary stimulation, catheters were placed in coronary artery and coronary sinus in a closed chest preparation. Plasma cate...

It has been reported that previously administered dipyridamole intensifies the coronary vasodilator action of adenosine compounds. In the present study, a combination of dipyridamole and ATP at doses that alone are ineffective was examined for its effect on the coronary sinus blood flow. In 10 anesthetized dogs, heart rate, arterial blood pressure, cardiac output, and coronary sinus blood flow ...

Effects of H1-receptor stimulation on coronary arterial diameter and coronary hemodynamics were examined in 11 patients with angiographically normal coronary arteries and without variant angina or resting angina. Selective H1-receptor stimulation was achieved by infusing histamine into the left coronary artery at a rate of 2.0 micrograms/min for 5 minutes after pretreatment with cimetidine (25 ...