the present study aims to investigate the effect of noscapine (0.5-2.5 µm), an alkaloid from the opium poppy, on primary murine fetal cortical neurons exposed to oxygen–glucose deprivation (ogd), an in vitro model of ischemia. cells were transferred to glucose-free dmem (dulbecco's modified eagle medium) and were exposed to hypoxia in a small anaerobic chamber. cell viability and nitric ox...

The mechanisms of perceptual decision-making are frequently studied through measurements of reaction time (RT). Classical sequential-sampling models (SSMs) of decision-making posit RT as the sum of non-overlapping sensory, evidence accumulation, and motor delays. In contrast, recent empirical evidence hints at a continuous-flow paradigm in which multiple motor plans evolve concurrently with the...

Neuroimaging research indicates that human intellectual ability is associated to brain structure including the thickness of the cerebral cortex. Most studies show that general intelligence is positively associated with cortical thickness in areas of association cortex allocated throughout both brain hemispheres. Changes in cortical thickness over time have been related to intelligence, but whet...

Reaction time variability across trials to identical stimuli may arise from both ongoing and transient neural processes occurring before trial onset. These processes were examined with dense-array EEG as humans completed saccades in a "gap" paradigm known to elicit bimodal variability in response times, including separate populations of "express" and regular reaction time saccades. Results indi...

The primary motor cortex (M1) contributes to the acquisition and early consolidation of a motor sequence. Although the relevance of M1 excitability for motor learning has been supported, the significance of M1 oscillations remains an open issue. This study aims at investigating to what extent retrieval of a newly learned motor sequence can be differentially affected by motor-cortical transcrani...