Nicotine is the major addictive compound in tobacco and is responsible for tobacco dependence. It is primarily metabolized to cotinine (COT) and trans-3'-hydroxycotinine (3HC) by the liver enzyme cytochrome P-450 2A6 (CYP2A6). The 3HC/COT ratio measured in the saliva of smokers is highly correlated with the intrinsic hepatic clearance of nicotine and, therefore, may be a useful non-invasive mar...

Cot/tpl2 is the only MAP3K that activates MKK1/2-Erk1/2 in Toll-like receptor-activated macrophages. Here we show that Cot/tpl2 regulates RSK, S6 ribosomal protein, and 4E-BP phosphorylation after stimulation of bone marrow-derived macrophages with lipopolysaccharide (LPS), poly I:C, or zymosan. The dissociation of the 4E-BP-eIF4E complex, a key event in the cap-dependent mRNA translation initi...

The objectives of the study were to determine the most effective and reliable means of restraining children on an ambulance cot and to develop recommended field procedures for emergency medical service providers. A series of crash tests at 48 km/h were conducted using convertible child restraints, car beds, and harness systems tested with 3-year, infant, and 6-year size dummies. Belt configurat...

Vertical sounding measurements within stratocumuli during two aircraft field campaigns, Marine Stratus/stratocumulus Experiment (MASE) and Physics of Stratocumulus Top (POST), are used to validate Moderate Resolution Imaging Spectroradiometer (MODIS) cloud optical thickness (COT), cloud liquid water path (LWP), and cloud effective radius (re). In situ COT, LWP, and re were calculated using 5 m ...

Operational nowcasting techniques for sea fog over the Yellow Sea rely on data from weather satellites because ground-based observations are hardly available. While there are several algorithms for detecting low stratus (LST) that are applicable to geostationary weather satellite data, sea fog retrieval is more complicated. These schemes mostly need ancillary data such as Cloud Optical Thicknes...

PURPOSE For clinicians, using opioid therapy for chronic noncancer pain (CNCP) often gives rise to a conflict between treating their patients' pain and fears of addiction, diversion of medication, or legal action. Consequent stresses on clinical encounters might adversely affect some elements of clinical care. We evaluated a possible association between chronic opioid therapy (COT) for CNCP and...

The constant on-time current-mode controlled (COT-CMC) switching dc-dc converter is stable, with no subharmonic oscillation in its current loop when a voltage ripple in its outer voltage loop is ignored. However, when its output capacitance is small or its feedback gain is high, subharmonic oscillation may occur in a COT-CMC buck converter with a proportional-integral (PI) compensator. To inves...

We compared the changes in ambulatory outcomes between men and women with symptomatic peripheral arterial disease (PAD) following completion of a supervised, on-site, treadmill exercise program, and we determined whether exercise training variables and baseline clinical characteristics were predictive of changes in ambulatory outcomes in men and women. Twenty-three men and 25 women completed th...

Figure A Overview of Steps Involved in a Cot Analysis. (A) Nuclear DNA is sheared into 200-500 bp fragments by high-speed blending, and (B) fragment size is checked by gel electrophoresis. (C) Sheared DNA is precipitated, dissolved in 0.03, 0.12, or 0.5 M sodium phosphate buffer (SPB), and aliquots are loaded/sealed into glass microcapillary tubes/ampoules. (D) One tube/ampoule is (E) placed in...

thermal cracking of a heavy liquid hydrocarbon was performed in a laboratory scale tubular reactor. central composite design (ccd), was used as an experimental design method. the design variables were coil outlet temperature (cot), feed flow and rate steam ratio. maximum yield of ethylene was 30.37 wt% at cot, residence time and steam ratio of 869oc, 0.208 s and 1.22 g/g, respectively. maximum ...