نتایج جستجو برای: cpe

تعداد نتایج: 1934  

Journal: :Applied and environmental microbiology 2008
Yasuhiro Miki Kazuaki Miyamoto Ikuko Kaneko-Hirano Kanako Fujiuchi Shigeru Akimoto

Clostridium perfringens is an important anaerobic pathogen causing food-borne gastrointestinal (GI) diseases in humans and animals. It is thought that C. perfringens food poisoning isolates typically carry the enterotoxin gene (cpe) on their chromosome, while isolates from other GI diseases, such as antibiotic-associated diarrhea, carry cpe on a transferable plasmid. However, food-borne GI dise...

2012
Zhijian Gao Bruce A. McClane

Clostridium perfringens enterotoxin (CPE) causes the symptoms associated with several common gastrointestinal diseases. CPE is a 35 kDa polypeptide consisting of three structured domains, that is, C-terminal domain I (responsible for receptor binding), domain II (responsible for oligomerization and membrane insertion), and domain III (which may participate in physical changes when the CPE prote...

2002
Eduardo A. Nillni Weihua Xie Lawrence Mulcahy Vanesa C. Sanchez William C. Wetsel

Cpe mice are obese, diabetic, and infertile. They have a mutation in carboxypeptidase E (CPE), an enzyme that converts prohormone intermediates to bioactive peptides. The Cpe mutation leads to rapid degradation of the enzyme. To test whether pro-thyrotropinreleasing hormone (TRH) conversion to TRH involves CPE, processing was examined in the Cpe mouse. Hypothalamic TRH is depressed by at least ...

2017
Zheng-Yun Liang Xing Kang Hong Chen Meng Wang Wen-Xian Guan

AIM To investigate the effects of Clostridium perfringens enterotoxin (CPE) on gastric cancer cells which highly expressed claudin-4 (CL4) protein. METHODS In this study, we detected expression of CL4 protein in different gastric cancer cell lines. Then, we investigated the effects of CPE on SGC7901 cells which highly expressed CL4 protein and the effects of CPE on subcutaneous tumor in nude ...

Journal: :Infection and immunity 1998
E U Wieckowski J F Kokai-Kun B A McClane

After binding, Clostridium perfringens enterotoxin (CPE) initially localizes in a small (approximately 90-kDa) complex in plasma membranes. This event is followed by formation of a second membrane complex, referred to as large (160-kDa) complex. Contrary to a previous hypothesis proposing that CPE inserts into intestinal brush border membranes (BBMs) when this toxin is localized in the small co...

2010
Leslie A. Mitchell Michael Koval

Clostridium perfringens enterotoxin (CPE), a major cause of food poisoning, forms physical pores in the plasma membrane of intestinal epithelial cells. The ability of CPE to recognize the epithelium is due to the C-terminal binding domain, which binds to a specific motif on the second extracellular loop of tight junction proteins known as claudins. The interaction between claudins and CPE plays...

Journal: :Infection and immunity 2014
Menglin Ma Abhijit Gurjar James R Theoret Jorge P Garcia Juliann Beingesser John C Freedman Derek J Fisher Bruce A McClane Francisco A Uzal

The ability of Clostridium perfringens type C to cause human enteritis necroticans (EN) is attributed to beta toxin (CPB). However, many EN strains also express C. perfringens enterotoxin (CPE), suggesting that CPE could be another contributor to EN. Supporting this possibility, lysate supernatants from modified Duncan-Strong sporulation (MDS) medium cultures of three CPE-positive type C EN str...

Journal: :Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 2014
S Fournier C Monteil M Lepainteur C Richard C Brun-Buisson V Jarlier C Ap-Hp Outbreaks Control Group

In 2009, following the occurrence of several outbreaks of carbapenemase-producing Enterobacteriaceae (CPE), a programme for controlling the spread of CPE was implemented in the 38 hospitals of the Assistance Publique-Hôpitaux de Paris, a 21,000-bed institution. This programme included recommendations to isolate, and screen for CPE, patients previously hospitalised abroad, and bundled measures t...

Journal: :The Journal of Cell Biology 1999
Noriyuki Sonoda Mikio Furuse Hiroyuki Sasaki Shigenobu Yonemura Jun Katahira Yasuhiko Horiguchi Shoichiro Tsukita

Claudins, comprising a multigene family, constitute tight junction (TJ) strands. Clostridium perfringens enterotoxin (CPE), a single approximately 35-kD polypeptide, was reported to specifically bind to claudin-3/RVP1 and claudin-4/CPE-R at its COOH-terminal half. We examined the effects of the COOH-terminal half fragment of CPE (C-CPE) on TJs in L transfectants expressing claudin-1 to -4 (C1L ...

2006
Annamari Heikinheimo Miia Lindström Per Einar Granum Hannu Korkeala

We found a prevalence of 18% for enterotoxin gene-carrying (cpe+) Clostridium perfringens in the feces of healthy food handlers by PCR and isolated the organism from 11 of 23 PCR-positive persons by using hydrophobic grid membrane filter-colony hybridization. Several different cpe genotypes were recovered. The prevalence was 3.7% for plasmidial IS1151-cpe, 2.9% for plasmidial IS1470-like-cpe, 0...

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