Cell penetrating peptides (CPPs) are those peptides that can transverse cell membranes to enter cells. Once inside the cell, different CPPs can localize to different cellular components and perform different roles. Some generate pore-forming complexes resulting in the destruction of cells while others localize to various organelles. Use of machine learning methods to predict potential new CPPs ...

The key building block of our flexible approach to the modular synthesis substituted cycloparaphenylenes (CPPs) is in spotlight. From this stage, depicted [8]- and [10]CPPs were synthesised two more steps, macrocyclization reductive aromatization. optoelectronic properties these nanorings compared those parent CPPs, as well tube-like solid state structure. More information can be found Research...

DESIGN This is a structured evidence-based review of all available studies on the development of abuse/addiction and aberrant drug-related behaviors (ADRBs) in chronic pain patients (CPPs) with nonmalignant pain on exposure to chronic opioid analgesic therapy (COAT). OBJECTIVES To determine what percentage of CPPs develop abuse/addiction and/or ADRBs on COAT exposure. METHOD Computer and ma...

BACKGROUND Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is one of the risk factors of impaired male fertility potential. Studies have investigated the effect of CP/CPPS on several semen parameters but have shown inconsistent results. Hence, we performed a systematic literature review and meta-analysis to assess the association between CP/CPPS and basic semen parameters in adult me...

The 2010 American Urological Association’s annual meeting brought fewer studies of chronic prostatitis/chronic pelvic pain (CP/CPPS) than in the past. That’s because most NIH research funding for CP/CPPS is now going toward long-term studies aimed at uncovering the cause, and it will be some time before we hear about the results. Nevertheless, the 2010 meeting brought news of potential new trea...

The etiology of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is unknown, which might associate with substantial morbidity and a greatly reduced quality of life (QOL), and significant healthcare cost. In this study, we investigated the symptoms, psychological burden and sexual dysfunction in men with chronic prostatitis/ chronic pelvic pain syndrome. A cross-sectional and multicent...

PURPOSE The objective of this study was to examine the psychological features and coping strategies of patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). MATERIALS AND METHODS The participants consisted of 55 military personnel suffering from CP/CPPS and 58 military personnel without CP/CPPS symptoms working at the Military Capital Hospital. The National Institutes of H...

OBJECTIVES Somatic/psychiatric symptoms are frequently found in chronic pain patients (CPPs). The objectives of this study were to determine 1) which somatic/psychiatric symptoms are more commonly found in acute pain patients (APPs) and CPPs vs community nonpatients without pain (CNPWPs) and 2) if somatic/psychiatric symptom prevalence differs between APPs and CPPs. DESIGN The above groups we...

CPPs (cell-penetrating peptides) facilitate the cellular uptake of covalently attached oligonucleotides, proteins and other macromolecules, but the mechanism of their uptake is disputed. Two models are proposed: direct movement through the phospholipid bilayer and endocytic uptake. Mitochondria are a good model system to distinguish between these possibilities, since they have no vesicular tran...

Many biologically active compounds, including macromolecules that are used as various kinds of drugs, must be delivered to the interior of cell or organelles such as mitochondria or nuclei to achieve a therapeutic effect. However, very often, lipophilic cell membrane is impermeable for these molecules. A new method in the transport of macromolecules through the cell membrane is the one based on...