Mutation of the adenomatous polyposis coli i t/'< i tumor suppressor gene initiates the majority of coloréela!(CR) cancers. One consequence of this inactivation is constitutive activation of ß-catenin/Tcf-mediated tran scription. To further explore the role of the APC/ß-catenin/Tcf pathway in CR tumorigenesis, we searched for mutations in genes implicated in this pathway in CR tumors lacking...

PURPOSE To evaluate the association between the AL/CR ratio and refractive state and explore the effectiveness of this ratio in the assessment of myopia, especially when combined with uncorrected visual acuity in schoolchildren among whom myopia is common. METHODS Cross sectional study. 4686 children from 6 primary schools, aged from 6 to 12 years were selected using the clustered-stratified ...

objective: the aim of present study was to evaluate the effects of oral administration of gallic acid (ga) for 21 days alone and in combination with exercise on nerve conduction velocity and sensory and motor functions in rats with sciatic nerve crush. materials and methods: seventy adult male wistar rats (250-300 g) were divided randomly into 7 groups with 10 in each: 1) control (cont), 2) cru...

Caloric restriction (CR) retards aging processes, extends maximal life span, and consistently improves insulin resistance in lower species. Insulin resistance is associated with cardiovascular disease, but data is lacking demonstrating that increased insulin sensitivity reduces atherosclerosis progression. We initiated a study in 32 adult cynomolgus monkeys to evaluate increased insulin sensiti...

PURPOSE The purpose of this study was to investigate chorus reading's (CR's) effect on speech effort during oral reading by adult stuttering speakers and control participants. The effect of a speech effort measurement highlighting strategy was also investigated. METHOD Twelve persistent stuttering (PS) adults and 12 normally fluent control participants completed 1-min base rate readings (BR-n...

We examined the pharmacokinetic (PK) and pharmacodynamic (PD) rationales to develop controlled release (CR) formulations of metformin. Unrestrained diabetic rats received the drug as intravenous bolus (i.v.), oral solution (p.o.), intra-duodenal bolus, 4-h infusion, or intra-colonic bolus. In addition, we developed two CR-gastroretentive dosage forms (CR-GRDF) that released the drug over 3 or 6...

Traditional film-screen radiography (FSR) has been useful in the recognition and evaluation of interstitial lung diseases, but is becoming increasingly obsolete. To evaluate the applicability of storage phosphor digital computed radiography (CR) images in the recognition of small lung opacities, we compared image quality and the profusion of small opacities between FSR and CR radiographs. We sc...

Abstract Low-temperature carburizing dramatically enhances the inherently low wear resistance of austenitic stainless steels due to formation a carbon-supersaturated solid solution, i.e. expanded austenite. The austenite from low-temperature has been intensively investigated. However, influence chemical composition steel on response not received same interest. This contribution addresses effect...

An almost CR-structure on a smooth manifoldM is a subbundle H(M) ⊂ T (M) of the tangent bundle of even rank endowed with operators of complex structure Jp : Hp(M) → Hp(M), J p = −id, that smoothly depend on p. A manifold equipped with an almost CR-structure is called an almost CR-manifold. The subspaces Hp(M) are called the complex tangent spaces to M , and their complex dimension, denoted by C...