BACKGROUND Creatine, Phosphocreatine, and creatine kinases, constitute an energy shuttle that links ATP production in mitochondria with cellular consumption sites. Myocytes and neurons cannot synthesize creatine and depend on uptake across the cell membrane by a specialized transporter to maintain intracellular creatine levels. Although recent studies have improved our understanding of creatine...

BACKGROUND Creatine is widely used as an ergogenic substance among athletes. Safety of prolonged creatine intake has been questioned, based upon case reports and animal data. We investigated the effect of prolonged creatine ingestion on renal function in animals with normal kidney function or pre-existing kidney failure, respectively. METHODS Male Wistar rats were randomly allocated to four e...

Many links are reported or suspected between the functioning of creatine, phosphocreatine, the creatine kinase isoenzymes or the creatine biosynthesis enzymes on one hand, and health or disease on the other hand. The aim of the present book was to outline our current understanding on many of these links. In this chapter, we summarize the main messages and conclusions presented in this book. In ...

AIMS Studies on the glycoprotein IIb-IIIa receptor blocker abciximab in patients undergoing percutaneous coronary intervention consistently show a reduction in procedure-related myocardial infarction. Some such infarcts are characterized by elevated creatine kinase or creatine kinase-MB, without apparent clinical symptoms. The clinical relevance of such 'creatine kinase leaks' has been question...

DIFFERENCES IN CREATINE RETENTION AMONG THREE NUTRITIONAL FORMULATIONS OF ORAL CREATINE SUPPLEMENTS. Mike Greenwood, Richard Kreider, Conrad Earnest, Christopher Rasmussen, Anthony Almada. JEPonline. 2003;6(2):37-43. Previous research has indicated that creatine retention is influenced by intramuscular creatine concentration and extracellular concentrations of glucose and insulin. This study ex...

the aim of this study was to determine the effect of creatine supplementation on sprint and skill performance in young soccer players. seventeen young soccer players (mean age: 17.18 ± 1.37 y, mean high: 169.6 ± 6.17 cm and mean weight: 61.67 ± 1.37 kg) participated in this study. subjects were assigned to either a creatine (5 g of cr, 4 times per day for 7 days) or a placebo group (same dosage...

Background It has been well-established that creatine monohydrate (CrM) increases whole body creatine retention and muscle creatine content. Extracts of Russian Tarragon (RT) have been reported to produce anti-hyperglycemic effects [1] and influence plasma creatine levels during the ingestion of CrM [2]. Theoretically, RT ingestion with CrM may promote greater creatine retention than ingesting ...