The majority of the statistical literature for the joint modeling of longitudinal and time-to-event data has focused on the development of models that aim at capturing specific aspects of the motivating case studies. However, little attention has been given to the development of diagnostic and model-assessment tools. The main difficulty in using standard model diagnostics in joint models is the...

This paper presents an interface for creating whole body motions of human and animal characters without reference motion Its basic function is to enable an imators to generate a natural motion by dragging a link to an arbitrary position with any number of links pinned in the global frame as well as other constraints such as desired joint angles and joint motion ranges Each constraint can be swi...

Osteoclasts are multinucleated cells of hematopoietic origin and are the primary bone resorbing cells. Numerous osteoclasts are found within the synovial tissue at sites adjacent to bone, creating resorption pits and local bone destruction. They are equipped with specific enzymes and a proton pump that enable them to degrade bone matrix and solubilize calcium, respectively. The synovial tissue ...

Cracking sounds emitted from human synovial joints have been attributed historically to the sudden collapse of a cavitation bubble formed as articular surfaces are separated. Unfortunately, bubble collapse as the source of joint cracking is inconsistent with many physical phenomena that define the joint cracking phenomenon. Here we present direct evidence from real-time magnetic resonance imagi...

the rank-k numerical range has a close connection to the construction of quantum error correction code for a noisy quantum channel. for noisy quantum channel, a quantum error correcting code of dimension k exists if and only if the associated joint rank-k numerical range is non-empty. in this paper the notion of joint rank-k numerical range is generalized and some statements of [2011, generaliz...

%ir Deall and Members of the Faculty of Medicine: I am deeply appreciative of the honour of addressing you to-day as the fourth Moynihan Lecturer. I am particularly happy because this invitation implies recognition of the specialty of orthopaedic surgery. I am very grateful that you have chosen me as a representative of my specialty to give this lecture. Arthroplasty is an operative procedure u...

223 International STakeholder NETwork (ISTNET) for Creating a Developmental Neurotoxicity Testing (DNT) Roadmap for Regulatory Purposes Kevin Crofton , Ellen Fritsche 2, Timo Ylikomi 3, and Anna Bal-Price 4 National Centre for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, RTP, NC, USA; IUF – Leibniz Research Institute for Environmental Medic...