We examined some of the metabolic events that regulate sensitizing cancer extract-induced leukocyte adherence inhi bition and found that human leukocytes adhere in a compara tively passive manner to glass in serum-free medium. Adher ence of leukocytes to glass did not require oxidative metabo lism, microtubules, microfilaments, or calcium entry, whereas leukocyte mobility excited by sensitizing...

Heightened airway reactivity is a cardinal feature of asthma and correlates with many clinical features of the illness, such as the acute response to bronchodilator drugs, the magnitude of diurnal fluctuations in lung function, and the amount of therapy required to control symptoms. Data have accumulated indicating that a reduction in airway reactivity can decrease asthma morbidity, and many ad...

Intractable asthma is a challenging clinical problem. This study was conducted to determine whether a subset of patients with Intractable asthma may be misdiagnosed and have a form of bronchiolitis instead and also to determine the effectiveness of macrolide therapy in these patients. Seventy six patients with Intractable asthma were re-treated with recommended maximal doses of oral prednisolon...

Chromonic phases are a family of lyotropic liquid crystals (LC) formed by ionic aromatic mesogens such as disodium cromoglycate (cromolyn), sunset yellow and others. It is well known that chromonic phases are oriented in the presence of external magnetic fields, leading to the observation of anisotropic NMR observables such as quadrupolar splittings or residual dipolar couplings. Despite the fa...

OBJECTIVE Patients with chronic idiopathic vulvar vestibulitis have increased mast cells when biopsied, and cromolyn has been suggested as a treatment. The purpose of this study was to assess the efficacy of 4% cromolyn cream in women with vulvar vestibulitis. METHODS A prospective, double blind, randomised, placebo controlled study was initiated at two centres. Patients with vulvar vestibuli...

BACKGROUND AND OBJECTIVES: The combination of cromolyn and ibuprofen is being investigated as a treatment for early Alzheimer's disease (AD). This study investigated the pharmacokinetics, safety, and tolerability of cromolyn and ibuprofen co-administration in healthy elderly adult volunteers. METHODS In this open-labeled study, 26 subjects, aged 55-75 years, received co-administration of inha...

An ordinal ranking system for clinically grading disability due to chronic asthma is described, by which to quantitate the changing course of individual patients during time-sequence observations. Experience over two years with 47 asthmatic patients undergoing various trials of disodium cromoglycate therapy indicates this index is very sensitive, reasonably reproducible in the hands of clinicia...