“In-labeled granulocytes were used to study the effects of histocompatibility factors on the migration of transfused granulocytes to infected sites. Fourteen alloimmunized and 20 nonalloimmunized patients received approximately 108 “In-labeled granulocytes from ABO-compatible. non-HIAmatched donors. and scans were performed over known infected sites. All 14 alloimmunized patients had lymphocyto...

BACKGROUND & OBJECTIVES Antibodies specific to donor human leucocyte antigen (HLA) play a critical role in graft rejection and graft loss. In recent years, techniques for their detection have evolved significantly providing an ever-increasing degree of sensitivity and specificity, from the conventional cell-based assays to the advanced solid-phase system based on the Luminex platform. Consensus...

Refractoriness occurs in many patients receiving multiple platelet transfusions. We used a sensitive ELISA assay to assess the utility of crossmatching HLA-A,B matched single donor platelets in 51 consecutive, typical refractory patients. Of the 222 transfusions evaluated at 1 to 4 hours posttransfusion, only 17 of 54 (31%) with positive crossmatches had corrected platelet count increments of g...

Twenty-six adult patients with preformed IgG donor lymphocytotoxic antibodies received primary liver allografts under FK 506 immunosuppression. The effect of the crossmatch-positive state on early graft function and on the immunopathological and histopathological findings was compared with that of 52 crossmatch-negative control recipients. The presensitized (crossmatch-positive) patients had pr...

“In-labeled granulocytes were used to study the effects of histocompatibility factors on the migration of transfused granulocytes to infected sites. Fourteen alloimmunized and 20 nonalloimmunized patients received approximately 108 “In-labeled granulocytes from ABO-compatible. non-HIAmatched donors. and scans were performed over known infected sites. All 14 alloimmunized patients had lymphocyto...

Tens of millions of new variable objects are expected to be identified in over a billion time series from theGaiamission. Crossmatching known variable sources with those from Gaia is crucial to incorporate current knowledge, understand how these objects appear in the Gaia data, train supervised classifiers to recognise known classes, and validate the results of the Variability Processing and An...

By PAT ROCHE, JR., M.D., RICHARD A. DODELIN, M.D. AND WALTER L. BLOOM, M.D. D EXTRAX is omie of the newest of macromolecular substances sihich have heems showns capal)le of expaiudimsg plasma volumme.15 Imi the past-, omse disadvanut-age to the imitravensous imujectionu of substances of large molecular size has heens the clumping amid! rounleaux formations of erythrocytes6’ which makes subseqin...

Multi-center kidney paired donation (KPD) is an exciting new transplant option that has not yet approached its full potential. One barrier to progress is accurate virtual crossmatching for KPD waitlists with many highly sensitized patients. Virtual crossmatch results from a large multi-center consortium, the National Kidney Registry (NKR), were analyzed to determine the effectiveness of flexibl...