Twenty-four washed cryoglobulin precipitates were examined for the presence of plasma fibronectin, immunoglobulins, complement components Clq and C3, and fibrinogen. Plasma fibronectin was detected in all preparations by immunodiffusion with antifibronectin serum, whereas the other components were found in some but not all of the cryoglobulins.

A patient with symptomatic primary cryoThis case constitutes, to our knowledge, globulinemia was followed for 9 yr and was the first example of amyloidosis associated found at autopsy to have generalized amylwith monoclonal lgG cryoglobulinemia, with oidosis. There was a monoclonal serum characterization of the monoclonal serum protein spike of lgG kappa type that was cryoglobulin, and also the...

Chronic hepatitis C virus (HCV) infection has only recently been recognized as the leading cause of mixed cryoglobulinemia.1,2 Rheumatoid factor B cells are part of the normal repertoire and significant titers of rheumatoid factors (RF) are induced during normal antiviral or antibacterial immune responses. Under the pressure of chronic antigen stimulation, RF repertoire is remodeled, and progre...

BACKGROUND Chikungunya virus (CHIKV), an arbovirus, is responsible for a two-stage disabling disease, consisting of an acute febrile polyarthritis for the first 10 days, frequently followed by chronic rheumatisms, sometimes lasting for years. Up to now, the pathophysiology of the chronic stage has been elusive. Considering the existence of occasional peripheral vascular disorders and some unexp...

Background Cryoglobulinaemic vasculitis is a small vessel that typically associated with hepatitis C viral infection (80%), however, it can also be lymphoproliferative disorders and autoimmune diseases. [1] It presents rheumatological, cutaneous or renal manifestations, in addition to peripheral neuropathy. significant morbidity mortality if left undiagnosed. The detection of cryoglobulins seru...

A 61-year-old male presented with 2 months of bone pain. Complete blood count showed Hb 10 g/dL, white blood cell count 4.5 109/L, and platelets 130 109/L. The peripheral smear contained visible agglutinates and a blue background color (panel A). Aggregates of amorphous particles mimicking lysed cells were observed microscopically (panels C-E) with smaller and less stained deposits (panel E arr...

Plasma postheparin lipolytic activity (PHLA) was measured on 50 patients with systemic lupus erythematosus (SLE). Plasma PHLA was significantly decreased in SLE patients. This decrease was most striking in the acute phase of the disease. There was a close relationship between decreased PHLA and immunologic factors indicative of the acute phase of SLE. These immunologic factors included shaggy a...