background and aims: a selective and sensitive high performance liquid chromatography-electrospray ionization mass spectrometry method has been established for determination of methotrexate in human plasma. methods: methotrexate was extracted from plasma with acetonitrile. the mobile phase consisted of acetonitrile-water-formic acid 74: 25: 1(v/v). twenty µl of sample was chromatographically an...

a chemiluminescence (cl) method has been developed for the determination of hydroxyzine (hyd) and its metabolite cetirizine (cet). the method is based on sensitizing effect of cet and hyd on the weak cl reaction between ru(phen)32+ and acidic ce(iv). a mechanism for the cl reaction has been proposed on the basis of uv-vis, fluorescent and cl spectra. by using the recommended procedure, the cali...

introduction: nowadays the necessity of the existence of a certain width of keratinized gingiva is emphasized upon to maintain periodontal health and prevent soft tissue recession around teeth and dental implants. this study was carried out to compare two gingival graft procedures including connective tissue graft and graft with a combination of collagen sponge with platelet-rich plasma and pla...

a rapid and sensitive hplc method has been developed for the quantification of mirtazapine (mrz), a noradrenergic and specific serotonergic inhibitor antidepressant (nassa) and its two major metabolites n-desmethylmirtazapine (ndm) and 8-hydroxymirtazapine (8-ohm) in human plasma. the separation was achieved using chromolith c18 column and a mobile phase of acetonitrile: phosphate buffer (ph=3,...

osteoporosis is a metabolic disease characterized by reduction in bone density and susceptibility to deformity and fracture. some studies show that osteoblasts can create inter-cellular free radicals that lead to cellular death. superoxide dismutase (sod) plays an essential role in cell defense against reactive oxygen metabolites. the purpose of this study was to measure the plasma sod activiti...

patients and methods seventy patients with chronic partial supraspinatus tears in magnetic resonance imaging were randomized into two groups; prp (n = 35) and pt (n = 35). before the treatment, at the end of the treatment and at the 12th month after the end of the treatment, range of motion (rom), visual analog scale (vas) for pain, disabilities of arm, shoulder and hand questionnaire (dash), n...

in this study, hydroxyapatite was coated on titanium substrates by plasma spraying process. a well-known porous and lamellar microstructure was found in the lateral and outer surface of coating. the phase composition was studied by xrd and the morphological and the microstructural aspects were investigated by scanning electron and optical microscopy. the hardness of coatings and substrates was ...

In this work, applicability of Particle in Cell-Monte Carlo Collisions (PIC-MCC) simulation method for better understanding of the plasma physical mechanisms and real important aspects of a plasma column driven by surface wave plasma discharges that is used in plasma antennas is examined. Via the implementation of geometry and physical parameters of the plasma column to an Object Oriented PIC-M...

the clinical use of prp therapy in the practical setting of orthopaedic fields is increasing partly because of the accessibility of devices that are used in outpatient preparation and delivery. another reason is the strong advertisement of prp procedures as the ultimate treatment and novel technology for knee problems by a few orthopaedic surgeons based on claims of abundant scientific evidence...