background: celiac disease (cd) has been found in up to 10% of the patients presenting with unexplained abnormal liver function tests (lft). as there is no precise data from our country in this regard, we investigated the prevalence of cd in patients presenting with abnormal lft. methods: from 2003 to 2008, we measured iga anti-tissue transglutaminase (t-tg) antibody (with elisa technique) with...

BACKGROUND Liver cirrhosis is one of the major causes of hospitalization and mortality in children. A wide spectrum of disorders including developmental abnormalities, infections, metabolic and genetic disorders can lead to liver cirrhosis in pediatric patients. Determination of its etiology is important for treatment, prevention of progressive liver damage, family counseling and prioritizing l...

Forty-two patients with autoimmune liver disease have been investigated. Renal tubular acidosis was detected in 60% of the patients with primary biliary cirrhosis, in 30% with active chronic hepatitis, and in one out of seven cases with cryptogenic cirrhosis. The presence of the defect of renal acidification was not related to the level of plasma potassium, copper, or total globulin, nor to the...

BACKGROUND Cirrhosis is one of the most severe liver complications, with multiple etiologies. The torque teno virus (TTV), also known as transfusion transmitted virus, which has a high incidence in the world population, is one of the possible increasing risk factors in patients with idiopathic fulminant hepatitis and cryptogenic cirrhosis. OBJECTIVES The aim of this study was to evaluate soli...

Liver Disease-Bouchier et al. MEDICAL JOURNAL gamma-globulin and that, in liver disease, the antibody is frequently a macroglobulin, while in D.L.E. it is predominantly a 7S gamma-globulin (Weir and Holborow, 1962). Positive A.N.F. tests were found in the absence of a positive L. Mackay and Wood, 1962). Unlike Calabresi and Greenberg's (1960) findings, antinuclear antibodies were not found in t...

Introduction: Celiac disease (CD) is a disease that involves many organs including the liver and is caused by autoimmune enteropathy. We aimed to compare the CD frequency between the cryptogenic cirrhosis and cirrhosis due to hepatitis B virus (HBV) and hepatitis C virus (HCV). Materials and methods: Patients with cryptogenic cirrhosis (n=83), HCV related cirrhosis (n=42) and HBV related cirrho...

BACKGROUND AND AIMS The adverse effect of acute hepatitis A in chronic liver disease is well known. The outcome of acute hepatitis E in chronic liver disease has not been extensively studied. The present study aimed to examine the clinical profile and outcome of patients with chronic liver disease and hepatitis E virus (HEV) superinfection, and the seroprevalence of hepatitis A and E infections...

Hereditary hemochromatosis (HH) is the most frequent genetic disease in populations of European origin. The HH gene was cloned by Feder et al. in 1996, and 2 major mutations were discovered: C282Y and H63D. Geographical differences with mutation frequencies have been published (1, 2) with a decreasing gradient of occurrence in Europe from north to south. HH leads to liver iron overload and rais...

A variety of signs and symptoms have been reported in regards to the typical and atypical presentations of CD. It is now well recognised that its onset may occur at any age and that atypical forms of CD are much more prevalent than its classic form (1).In this case, where the patient presented with high BMI and evidence of grade I of fatty liver disease, CD was suspected due to mildly abnormal ...