Colony-stimulating factor 1 (CSF-1) regulates the survival, proliferation, and differentiation of mononuclear phagocytes. It is expressed as a secreted glycoprotein or proteoglycan found in the circulation or as a biologically active cell-surface glycoprotein. To investigate tissue CSF-1 regulation, CSF-1-null Csf1(op)/Csf1(op) mice expressing transgenes encoding the full-length membrane-spanni...

Recent activities in the field of time and frequency metrology pursued at PTB are reviewed. Quasi-continuous operation of the cesium fountain frequency standard CSF1 enabled us to assess the performance of the older primary clocks CS1 and CS2 much better than previously possible. On average, the CSF1 and CS2 frequencies deviated by less than 5 parts in 10 during more than 2 years, which is well...

Fedarko, N.S., Jain, A., Karadag, A., Van Eman, M.R. & Fisher, L.W. (2001) Elevated serum bone sialoprotein and osteopontin in colon, breast, prostate, and lung cancer. Clinical Cancer Research, 7, 4060– 4066. Flamant, S., Kortulewski, T., Dugray, A., Bonnet, M.L., Guillier, M., Guilhot, F., Bourhis, J.H., Vainchenker, W., Roux, D.T.L. & Turhan, A.G. (2005) Osteopontin is upregulated by BCR-ABL...

astroparesis is a clinical condition associated with Gdelayed gastric emptying in the absence of mechanical obstruction. Patients present with nausea, vomiting, bloating, and early satiety. The underlying cause may be related to diabetes but also can be caused by upper gastrointestinal surgery, neurologic disease, collagen vascular disease, viral infections, and drugs. In approximately 35% of p...

PURPOSE Diffuse-type tenosynovial giant cell tumor (D-TSGCT) is an aggressive proliferation of synovial-like mononuclear cells with inflammatory infiltrates. Despite the COL6A3-CSF1 gene fusion discovered in benign lesions, molecular aberrations of malignant D-TSGCTs remain unidentified. EXPERIMENTAL DESIGN We used fluorescent in situ hybridization and in situ hybridization to evaluate CSF1 t...

A prospective multicenter trial of 119 children 1 to 18 years of age with newly diagnosed aplastic anemia (AA) was conducted, comparing treatment using antithymocyte globulin (ATG), cyclosporine (CyA), and danazol (DAN) with or without rhG-CSF (400 mg/m2, day on days 1-90). All children with very severe AA received rhG-CSF (VSAA group, n 5 50). The other children were randomized to receive ATG,...

Purpose: Binding of colony-stimulating factor 1 (CSF1) ligand to the CSF1 receptor (CSF1R) regulates survival of tumor-associated macrophages, which generally promote an immunosuppressive tumor microenvironment. AMG 820 is an investigational, fully human CSF1R antibody that inhibits binding of the ligands CSF1 and IL34 and subsequent ligand-mediated receptor activation. This first-in-human phas...

PURPOSE We recently described two types of stromal response in breast cancer derived from gene expression studies of tenosynovial giant cell tumors and fibromatosis. The purpose of this study is to elucidate the basis of this stromal response--whether they are elicited by individual tumors or whether they represent an endogenous host reaction produced by the patient. EXPERIMENTAL DESIGN Strom...

Self-renewal and differentiation of spermatogonial stem cells (SSCs) provide the foundation for testis homeostasis, yet mechanisms that control their functions in mammals are poorly defined. We used microarray transcript profiling to identify specific genes whose expressions are augmented in the SSC-enriched Thy1(+) germ cell fraction of mouse pup testes. Comparisons of gene expression in the T...

PURPOSE Adjuvant treatment may improve survival in early-stage squamous cell carcinoma (SCC) of the lung; however, the absolute gain is modest and mainly limited to stage II-IIIA. Current staging methods are imprecise indications of prognosis, but high-risk patients can be identified by gene expression profiling and considered for adjuvant therapy. EXPERIMENTAL DESIGN The expression of 29 gen...