Bacillus licheniformis RM44 was isolated from hot spring near Karachi and screened forthe production of extracellular amylase Amy RM44. Amy RM44 was purified to homogeneityon a single step by affinity chromatography using insoluble corn starch. The molecular weightof Amy RM44 was estimated to be 66 kDa by SDS–PAGE and zymographic analysis. Nine foldpurification was achieved with the specific ac...

the purpose of this study was to prepare and characterize microspheres loaded by cyclosporine a(cya)-cyclodextrin (cd) complex. to achieve this goal, plga microspheres loaded by cya cd complex were prepared by multiple emulsificationsolvent evaporation methods.morphology, size, encapsulation efficiency and drug release from these microspheres were evaluated. microscopic evaluation of microspher...

Piroxicam-beta-cyclodextrin is a complex of the established nonsteroidal antiinflammatory drug (NSAID) piroxicam and an inert cyclic macromolecule, beta-cyclodextrin. In clinical trials in patients with rheumatic diseases or pain arising from other conditions, it was as effective an analgesic as standard piroxicam, and showed a faster onset of action on the first day of treatment. In short term...

A series of novel bis(beta-cyclodextrin)s tethered with organoselenium linkers, i.e., 6,6'-(o-phenylene-diseleno)-bridged bis(beta-cyclodextrin) (2), 6,6'-[2,2'-diselenobis(benzoyloxy)]-bridged bis(beta-cyclodextrin) (3), and 6,6'-[2,2'-diselenobis[2-(benzoylamino)ethylamino]]-bridged bis(beta-cyclodextrin) (4), were synthesized from beta-cyclodextrin (1). The inclusion complexation behavior of...

The cyclical structure of this molecule has been previously employed in various industries: In low fat dairy spreads, hydrophobic cholesterol is removed using a process by lodging it inside the cyclodextrin. Hydroxypropyl-β-cyclodextrin (HPβCD) is the principle active compound in the fabric odour eliminator Febreze, the cyclodextrin simply envelops any malodorous molecules leaving even my runni...

We describe the complexation of isolated and native lipoproteins by natural macrocyclic polymers of glucose ("cyclodextrins"). Treatment of serum with cyclodextrin produces an immediate flocculation of the lipoproteins. The formation of cyclodextrin-lipoprotein complexes was evident on agarose electrophoresis gels. The concentration-dependent ability of alpha-cyclodextrin to precipitate chylomi...

Electrochemistry of cyclodextrins (CDs) and cyclodextrin inclusion complexes with different pharmaceutical compounds is reviewed. The article highlights some electrochemical investigations of the CD-drugs interactions in solution. Cyclodextrin modified electrodes and their applications as electrochemical sensors in pharmaceutical analysis based on the self-assembly of CD derivatives on metal el...

rides consisting of six or more cr-1,4-linked Dglucopyranose units which possess primary hydroxyl groups at the C-6 positions and secondary hydroxyl groups at the C-2 and C-3 positions. Because cyclomaltooligosaccharides have a hydrophobic and optically active interior, they have been utilized as transporters of hydrophobic molecules and as small molecular mimics of enzymes. One of the cyclomal...