BACKGROUND Diseases that affect the buccal cavity are a public health concern nowadays. Chlorhexidine and nystatin are the most commonly used drugs for the control of buccal affections. In the search for more effective antimicrobials, nanotechnology can be successfully used to improve the physical chemical properties of drugs whilst avoiding the undesirable side effects associated with its use....

OBJECTIVE To compare the effect of different reaction temperatures on the cyclization and coupling reactions of the Toruzyme CGTase influencing the yield of cyclodextrins (CDs) and to study the solubility of paracetamol with CDs. MATERIAL AND METHOD Type and amount of CDs were analyzed by HPAEC-PAD. The stability constants for the inclusion complex formed between CDs and paracetamol were dete...

The effect of the reaction conditions (substrate concentration, enzyme dosage, and pH) on cyclodextrin production by cyclodextrin glucanotransferase from Bacillus megaterium was investigated by applying mathematical modeling methods. Adequate models were developed and they were used for determination of the optimal conditions for maximal formation of beta-cyclodextrins at minimal concentrations...

Abstract Hydroxycitronellal has been widely used in foods, beverages, perfumery and cosmetics. It can also be to treat anxiety. The major drawbacks regarding the use of hydroxycitronellal are related water insolubility, volatility, instability, sensitization. To overcome these concerns, β-cyclodextrin was adopted as wall material encapsulate this work. Hydroxycitronellal-β-cyclodextrin inclusio...

Cyclodextrins are naturally oligosaccharides which had cyclic glucopyranoside units even if six to form α-cyclodextrin (α-CD), seven β-cyclodextrin (β-CD) or eight γ-cyclodextrin (γ-CD) and some other derivatives. It has a truncated cone shape with hydrophobic cavity hydrophilic from the external surface of cyclodextrins. Gold nanoparticles incorporated cyclodextrins enhanced optical electrical...

The product specificity and pH optimum of the thermostable cyclodextrin glycosyltransferase (CGTase) from Thermoanaerobacterium thermosulfurigenes EM1 was engineered using a combination of x-ray crystallography and site-directed mutagenesis. Previously, a crystal soaking experiment with the Bacillus circulans strain 251 beta-CGTase had revealed a maltononaose inhibitor bound to the enzyme in an...

Curved corannulene (Cor) can produce reactive oxygen species (ROS) in a controlled manner due to the large dipole moment. However, the poor aqueous solubility of Cor necessitates the employment of solubilization vehicles. This work revealed that PEGylation was less efficient than the cyclodextrin complexation regarding ROS production.

Herein we report the efficient extraction of aromatic analytes from crude oil and tar balls using multiple cyclodextrin derivatives. The known propensity of the cyclodextrins to bind hydrophobic guests in their hydrophobic interiors enhanced the extraction of aromatic analytes from the oil layer to the aqueous layer, with methyl-β-cyclodextrin and β-cyclodextrin providing the most significant e...