forty renal allograft patients with three months under immunosuppression by cycloserine were examined for their gingival overgrowth and it's correlation with several parameters including the trough levels of blood cyclosporine and it's metabolites measured by the fluorescence polarization immunoassay technique. no correlation was found between the scores of gingival overgrowth and both the age ...

background corticosteroids are used to induce remission in auto-immune hepatitis. they are not universally effective; therefore, alternative treatments are needed. in this study cysclosporine-a has been compared with prednisolone as an alternative treatment in a randomized controlled trial. this paper is an interim analysis of an ongoing clinical trial. methods sixteen years and older consentin...

introduction: previous studies have indicated a relationship between mptp pore and av nodal rate-dependent properties. the aim of present study was to determine acute direct effects of cyclosporine on extracellular field potential of isolated rabbit av node during experimental atrial fibrillation. methods: in one group of male new zealand rabbits (1.5-2.5 kg) cumulative concentrations of cyclos...

Objective. To study the effect of immunomodulators on learning and memory and on cholinergic receptor sensitivity. Methods. Animals were initially treated for a period of 8 days with cyclosporine/levamisole/saline. They were then subjected to passive avoidance training and 48 hrs later, the retention test for the passive avoidance task was conducted. Twenty-four hours after the retention tests ...

A lot of researches have investigated the effects of topical cyclosporine A on the eye surface layers’ diseases. By now the main limitation in cyclosporine application is the low permeation of the drug into the posterior segments of the eye. The aim of present study was to formulate high permeable dosage form can be beneficial in the topical treatment of the uveitis. To reach higher corneal dru...

purpose: to investigate the efficacy of topical cyclosporine a 2% in treating and preventing recurrent graft rejection episodes after penetrating keratoplasty (pkp) in patients with history of previous rejection episodes. methods: in this clinical trial, eligible pkp patients were randomly given topical cyclosporine a 2% or placebo in addition to a standard corticosteroid regimen for an episode...

Background: Cyclosporine-A(CsA) is an immunosuppressive polypeptide which is produced byTolypocladium inflatum gams and can cause infertility. Satureja hortensis or summer savory is a one year plant from Lamiaceae family which is used as a motive drug, anti-bloat, anti-infection and sexual power enhancer. According to positive effects of S. hortensis and negative effects of CsA we will evaluate...

Background: Cyclosporine-A (CsA) is an immunosuppressive drug used in organ transplantation. Side effects of CsA such as body weight loss and decreased fertility rate have been reported. Satureja hortensis is a therapeutic plant with antioxidant properties. Materials and Methods: 24 adult male rats weighing 200±20 gr were divided into three groups (n=8): control group which received no treatmen...

A 47 year old woman is reported who had life-threatening bleeding due to the spontaneous development of factor VIII:C inhibitor. Cyclosporin combined with prednisone resulted in a full recovery and complete elimination of antibody even when other therapeutic facilities failed to be effective.