نتایج جستجو برای: cyp2c19 polymorphisms

تعداد نتایج: 68456  

2010
Junji Saruwatari Takateru Ishitsu Kazuko Nakagawa

Genetic polymorphisms in the genes that encode drug-metabolizing enzymes are implicated in the inter-individual variability in the pharmacokinetics and pharmaco-dynamics of antiepileptic drugs (AEDs). However, the clinical impact of these polymorphisms on AED therapy still remains controversial. The defective alleles of cytochrome P450 (CYP) 2C9 and/or CYP2C19 could affect not only the pharmaco...

2012
Su-Jun Lee

More than 30 years of genetic research on the CYP2C19 gene alone has identified approximately 2,000 reference single nucleotide polymorphisms (rsSNPs) containing 28 registered alleles in the P450 Allele Nomenclature Committee and the number continues to increase. However, knowledge of CYP2C19 SNPs remains limited with respect to biological functions. Functional information on the variant is ess...

2012
Anichavezhi Devendran Chakradhara Rao Satyanarayana Uppugunduri Rajan Sundaram Deepak Gopal Shewade Krishnamoorthy Rajagopal Adithan Chandrasekaran

CYP2C19 is a polymorphic enzyme involved in the metabolism of clinically important drugs. Genotype-phenotype association studies of CYP2C19 have reported wide ranges in the metabolic ratios of its substrates. These discrepancies could be attributed to the variations in the promoter region and this aspect has been reported recently. The observations in the recent reports on the influence of prom...

2015
Jian Liu Xiao-Yan Nie Yong Zhang Yun Lu Lu-Wen Shi Wei-Min Wang

BACKGROUND To investigate the contributions of CYP2C19 polymorphisms to the various clopidogrel responses tested by thrombelastography (TEG) in Chinese patients with the acute coronary syndrome (ACS). METHODS Patients were screened prospectively with ACS diagnose and were treated with clopidogrel and aspirin dual antiplatelet therapy. CYP2C19 loss of function (LOF) and gain of function (GOF) ...

Journal: :Drug testing and analysis 2017
Tian Lan Ling-Jing Yuan Xiao-Xia Hu Quan Zhou Jun Wang Xiang-Xin Huang Da-Peng Dai Jian-Ping Cai Guo-Xin Hu

CYP2C19 is an important member of the cytochrome P450 (CYP450) enzyme super family and is responsible for clearing approximately 10% of commonly used clinical drugs that undergo phase I metabolism. Genetic polymorphisms of CYP2C19 significantly influence the efficacy and safety of some drugs, which might cause undesirable adverse effects or cure failure at standard dosages. The aim of this stud...

2016
Kai Chang Zhongyong Jiang Chenxia Liu Junlong Ren Ting Wang Jie Xiong

In recent years, the genetic factor has become one of the important predisposing factors of nephropathy susceptibility. There is a high incidence of nephropathy in CCVd. The CYP2C19 enzyme metabolizes most the drugs, including proton pump inhibitors commonly used medicines to treat CCVd, CYP2C19 genetic polymorphisms is association with multi-pathogenesis factors of nephropathy. The purpose of ...

2012
Dong-Jik Shin Jisun Kwon Ah-Ram Park Yousun Bae Eun-Soon Shin Sungha Park Yangsoo Jang

PURPOSE The cytochrome P450 2C19 (CYP2C19) metabolizes arachidonic acid to produce epoxyicosanoid acids, which are involved in vascular tone and regulation of blood pressure. Recent findings suggest that CYP2C19 gene might be considered as a novel candidate gene for treatment of cardiovascular disease. The aim of the present study was to evaluate the association between two variants, CYP2C19* 2...

2013
Mercedes Zafra-Ceres Tomas de Haro Esther Farez-Vidal Isabel Blancas Fernando Bandres Eduardo Martinez de Dueñas Enrique Ochoa-Aranda Jose A. Gomez-Capilla Carolina Gomez-Llorente

BACKGROUND Estrogen receptor-positive breast cancer tumors depend on estrogen signaling for their growth and replication and can be treated by anti-estrogen therapy with tamoxifen. Polymorphisms of the CYP2D6 and CYP2C19 genes are associated with an impaired response to tamoxifen. The study objective was to investigate the impact of genetic polymorphisms in CYP2D6 and CYP2C19 on the pharmacokin...

2012
Yun Shi Guo-jun Luo Li Zhang Ji Shi Dao-quan Zhang Jian-min Chen Xiao-bo Chen Zhuo-dong Li Qing Zhao

OBJECTIVES The purpose of this study is to explore the relationship between the interactions of CYP2C19 gene polymorphisms and several environmental factors and oesophageal squamous cell carcinoma (OSCC). METHODS In a case-control study of OSCC patients (n = 350) and healthy controls (n = 350), we investigated the roles of polymorphism in the CYP2C19 gene by the use of polymerase chain reacti...

Journal: :Medicina 2014
Gustavs Latkovskis Inga Urtane Agnese Knipse Raitis Peculis Inese Cakstina Janis Klovins Andrejs Erglis

BACKGROUND AND OBJECTIVE Additional loading doses and higher maintenance doses (MDs) have been used to overcome hyporesponsiveness of clopidogrel. We aimed to investigate whether genetic polymorphisms of two cytochromes (CYP2C19 and CYP2C9) and ABCB1 modify effect of such dose-adjustment strategy. MATERIALS AND METHODS We enrolled 118 patients undergoing elective or acute percutaneous coronar...

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