OBJECTIVE To assess the role of endometrial thickness on vaginal ultrasound assessment and menstrual history in predicting endometrial hyperplasia in women with polycystic ovary syndrome (PCOS) who presented with infertility due to anovulation. METHODS This was a prospective study in a university referral-based fertility and endocrine clinic. Fifty-six women with PCOS presenting with infertil...

BACKGROUND The differential diagnosis between atypical endometrial hyperplasia and endometrial carcinoma is often difficult and based on controversial criteria. Cell kinetic parameters may be helpful. DESIGN Cell proliferation, apoptosis and Bcl-2 expression were evaluated in benign endometrium, non atypical and atypical endometrial hyperplasia and endometrial carcinoma. The results were comp...

PURPOSE Endometrial carcinoma (EC) is common in the population and the most frequent extracolonic malignancy in hereditary nonpolyposis colorectal carcinoma (HNPCC)/Lynch syndrome. We characterized precursor lesions of endometrioid EC to identify markers of malignant transformation and tumor progression. EXPERIMENTAL DESIGN Serial specimens of normal endometrium, simple hyperplasia, complex h...

OBJECTIVE This study was aimed to investigate endometrial histology and to find predictable clinical factors for endometrial disease (hyperplasia or cancer) in women with polycystic ovary syndrome (PCOS). METHODS We investigated the endometrial histology and analyzed the relationship between endometrial histology and clinical parameters, such as LH, FSH, estradiol, testosterone, fasting and 2...

background hysteroscopy is the gold standard method for diagnosis of intrauterine pathologies. current study is a review of hysteroscopic findings performed over a period of 5 years in patients with abnormal uterine bleeding (aub). objective the aim of this study was a review of hysteroscopic findings performed over a period of 5 years in patients with abnormal uterine bleeding (aub). patients ...

This study aimed to compare the effectiveness of ovariohysterectomy operations with aglepristone and aglepristone+PGF2α treatment protocols, preceded by clinical, gynaecological, and ultrasonographical examinations and total blood and hormone analyses in bitches. Furthermore, the influence of initial progesterone (P4) concentrations and uteral diameters on the efficacy of pyometra treatment was...

Long-term application of Tamoxifen (TAM) is usually recommended for hormone receptor positive breast cancer patients. Unfortunately, TAM will inevitably increase the incidence of endometrial hyperplasia even endometrial cancer. Despite of substantial investigations, no effective approaches to prevent TAM-induced endometrial carcinogenesis have been acknowledged. In this study, we found that inh...

BACKGROUND The endometrial hyperplasia measured by ultrasound in polycystic ovary syndrome (PCOS) women is strongly related to pathologic endometrial thickness, but there is no consensus on the relation between serum luteinizing hormone (LH) and either of these factors: pathologic endometrial hyperplasia and body mass index (BMI). MATERIALS AND METHODS In this observational cross-sectional st...

Hysteroscopy and uterine curettage are required in cases of atypical hyperplasia in premenopause and in all cases of hyperplasia with/without atypia in postmenopausal women. Biopsic curettage is the method of choice in the diagnosis of endometrial pathology. Transvaginal ultrasound and Doppler examination are useful in assessing the risk of endometrial hyperplasia or endometrial cancer in postm...

OBJECTIVE We sought to determine the predictors of treatment response in simple endometrial hyperplasia without atypia. MATERIAL AND METHODS We prospectively treated 67 women with simple endometrial hyperplasia without atypia who were administered cyclic oral medroxyprogesterone acetate 10 mg/day for 12 days of luteal phase for 3 months and underwent control endometrial sampling after treatme...