Abstract Background Interleukin-4 (IL-4), a pleiotropic anti-inflammatory cytokine, is produced mainly by activated T helper 2 (Th2). Hepatocellular carcinoma (HCC) typical inflammation-related cancer. Alterations influencing IL-4 expression may disturb immune response and be associated with HCC risk. We aimed to verify role of IL4 gene polymorphism ( IL-4-589C/T (rs2243250 )) in HCV-related he...

Context: The relationship between polymorphisms in the location of cytokine tumor necrosis factor (TNF-α) and lung cancer has been investigated many studies. Accordingly, present meta-analysis study focused on TNF-α-238 gene cancer. Methods: Articles were collected from Google Scholar, Scopus, PubMed electronic databases until 2022. articles searched based keywords “Lung cancer,” “238 Gene”, “t...

Background. Cytokine and toll-like receptor gene polymorphisms may impact oral tolerance formation in infants. Objective: To determine the genotype distribution of IL-10 (G1082A, C592A) TLR 4 (Asp299Gly) children with different family history allergy residing Grodno region; to analyze association between concentrations fecal calprotectin (FCP) urine eosinophil protein X (UEoPX) Material Methods...

interleukin-1β (il-1β), the prototypical pro-inflammatory cytokine, is produced by macrophages following exposure to bacterial products. its role is to act upon several cell types at the site of infection to stimulate the production of pro-inflammatory molecules that will cause increase in vascular permeability. therefore, il-1β regulates the initiation and development of acute inflammation tha...

background: the pro-inflammatory cytokine, tumor necrosis factor-alpha (tnf-α), is a pathogenic element for a number of disorders. previous studies have reported that the -1031 t/c and -238 g/a polymorphisms in the promoter region of the tnf-α gene are important factors in reproductive-related disorders. one of the most common gynecological diseases of women during the reproductive years is end...

Background/Aim: Alopecia areata (AA), which is characterized by hair loss, an inflammatory autoimmune disease. Tumor necrosis factor-alpha (TNFα) a potent proinflammatory cytokine that has highly significant role in and immune responses. The aim of this study to evaluate whether there relationship between TNFα -238 G/A gene polymorphism AA the Turkish population. Methods: In case-control study,...

PURPOSE Biochemotherapy can achieve high response rates in advanced melanoma, but the factors that influence regression and survival remain unknown. The present exploratory study tested the hypothesis that cytokine gene polymorphisms predict clinical outcome in stage IV melanoma patients treated with biochemotherapy. EXPERIMENTAL DESIGN Ninety patients with stage IV melanoma were treated with...