conclusions in conclusion, ctp-hbcag18-27-tapasin could reduce apoptosis of cd8+ t cells, increase the percentages of ifn-γ+ cd8α+ t cells, and elicit cell-mediated immunity in hla-a2 transgenic mice; these processes were associated with activation of the pi3k/akt signaling pathway. results the results showed that ctp-hbcag18-27-tapasin significantly increased the percentages of ifn-γ+ cd8α+ t ...

background: polysaccharides have long been used as immune-modulators in various pathologic conditions including inflammation and solid malignancies. objective: to evaluate the effects of zymosan and betaglucan on cytotoxic reactions in an effectortarget conjugate system. methods: blood was obtained from 20 healthy subjects; purified mononuclear leukocytes (monocytes and lymphocytes) were extrac...

There are some reports on the lignan constituents of Linum spp. In this study, we investigated the cyototoxicity of Linum spp. in vitro cultures for the first time. If they show significant cytotoxic activity, they will be valuable candidates for isolation of cytotoxic compounds in large scale from them by tissue culture technology. In our study, we chose normal root, hairy root and calli cultu...

methanolic extract of 15 iranian medicinal plants were prepared and tested for their cytotoxic activities against three cancer cell lines (mcf7, hepg2 , wehi164) and one normal cell line (mdbk). some plants showed cytotoxic activities. the extract of ferula szowitsiana root, which proved to be the most active, was chosen for further phytochemical studies. the major compounds of the most potent ...

In vitro studies evaluating the cytotoxic potential of substances released from dental adhesives are lacking. The purpose this study was to compare cytotoxicity extracts Scotchbond Universal and Optibond Solo Plus, an adhesive in experimental phase: T1. 3T3 mouse fibroblast cells MG-63 osteoblast-like human osteosarcoma were exposed for 24 h serial extract dilutions. Cytotoxicity determined usi...

it has been reported that different species of euphorbia (euphorbiaceae) have antitumor activity. some reports also show that these plants have potential cytotoxic effect against different cell lines. in a program to screen the cytotoxicity of iranian native plants, euphorbia macroclada boiss. was collected, identified, and the cytotoxic activity of dichloromethane, ethylacetate, methanol extra...

the objective of the study was to evaluate the cytotoxic effects of aqueous extract of cucumis melo fruit on human prostate cancer cell line (pc-3) using mtt and neutral red assays. the crude aqueous extract of c. melo was prepared by cold maceration method, filtered, concentrated and tested on pc-3 cell line. dose-dependent cytotoxic activities were exhibited on human prostate carcinoma pc-3 c...

quinazolinones are a group of fused heterocyclic compounds which have valuable biological properties including cytotoxic, antibacterial and antifungal activities. thiazole group-containing compounds have been also reported to have a wide range of biological activities such as antitumor, anti-inflammatory, analgesic and antibacterial effects. due to valuable cytotoxic effects of both thiazole gr...

DNA intercalators belong to aromatic heterocyclic compounds interacting reversibly with DNA. These compounds have been used extremely as cytotoxic agents against cancer. In this study, the synthesis and biological activity of some novel derivatives of cyclopenta [b] quinoline-1, 8-dione as new intercalating agent were investigated. Twenty novel derivatives of cyclopenta [b] quinoline-1, 8-dione...