scorpion venom toxicity is of major concern due to its influence on human activities and public health. we investigated the in-vitro process of cell death caused by two iranian scorpions odontobuthus doriae and bothutus salceyi venom on human cell lines. the aim of this study was to provide further information about triggering cell death and suggestion of methods for the elimination of unwanted...

cancer is a group of diseases characterized by uncontrolled proliferation of abnormal cells. because of the severe side effects and resistance to the traditional chemotherapeutic agents, the necessity for discovery of new anticancer drugs is a crucial topic. in the present study we synthesized new derivatives of 2-(4-fluorophenyl)- n -halophenylacetamide and assessed their cytotoxicity against ...

background: calprotectin is cytotoxic agent that its anti-tumor effects are governed through suppression of topoisomerase ii a key enzyme in apoptosis. in previous studies, cytotoxicity and apoptotic effects of calprotectin are shown on different cancer cell lines, but not human gastric cancer cell lines. in the present study, cytotoxicity and apoptotic effects of calprotectin on human gastric ...

Cancer is a general term applied to some malignant diseases that may affect different parts of the body. Recently there has been a great effort in finding and synthesizing effective anticancer drugs. Effective compounds from plants such as periwinkle and taxus, give us a bright view of the future of plants and their anticancer agents. The alkaloids vincristine and vinblastine which were discove...

studies on biomedical applications of nanoparticles are growing with a rapid pace. in medicine, nanoparticles may be the solution for multi-drug-resistance which is still a major drawback in chemotherapy of cancer. in the present study, we investigated the potential cytotoxic effect of silver nanoparticles (ag nps) and silver ions (ag+) in both parent and tamoxifen-resistant t47d cells in prese...

In vitro Cytotoxic Effect of Biosurfactant Extracted from Bifidobacterium spp. on MCF-7 and WRL68 Cell Lines

cranesbill (geranium species) are used traditionally as tonic, antidiabetic, antidiarrheal, antihemorrhoidal, diuretic and for the treatment of cough, fever, tonsillitis, urticaria, kidney pain and gastrointestinal ailments. the leaves of some geranium species are consumed in traditional turkish cousin as salad or added to pastry. in the present study, different extracts from g. psilostemon and...

a series of 2-amino-4-aryl-3-cyano-7-(dimethylamino)-4 h -chromenes was synthesized by condensation of 3-(dimethylamino)phenol, an aromatic aldehyde and malonitrile in ethanol containing piperidine. the assignments of the structure of all synthesized compounds were based on spectral data (ir, mass and 1 h nmr). the cytotoxic activities of the synthesized compounds against six human tumor cell l...