One of the emerging therapeutic strategies for targeted therapy of cancer is the use of chimeric proteins. The p28 peptide has the ability of selective entrance and activating apoptosis in breast cancer cells. The NRC antimicrobial peptide showed cytotoxic activity on various breast cancer including drug-resistant variants but also normal cell lines. Here we designed a chimeric protein consiste...

One of the emerging therapeutic strategies for targeted therapy of cancer is the use of chimeric proteins. The p28 peptide has the ability of selective entrance and activating apoptosis in breast cancer cells. The NRC antimicrobial peptide showed cytotoxic activity on various breast cancer including drug-resistant variants but also normal cell lines. Here we designed a chimeric protein consiste...

background: flavonoids have a variety of biological activities, such as anti-allergic, anti-inflammatory, anti-oxidative, free radical scavenging, and anti-mutagenic. methods: the cytotoxic effects of three synthesized flavonoid derivatives (k3, k4 and k5) were evaluated against hela , mda-mb -231 and ht-29 cancer cells using mtt assay. results: the results showed that these flavonoids were not...

INTRODUCTION Gene therapy could prevent bleeding in hemophilia. However, antibodies could inhibit coagulation, while cytotoxic T lymphocytes could destroy modified cells. The immaturity of the newborn immune system might prevent these immune responses from occurring after neonatal gene therapy. MATERIALS AND METHODS Newborn dogs, cats, or mice were injected intravenously with a retroviral vec...

Objective(s):This study aims at exploring cytotoxic activity of different peptides derived from VSVG protein against MCF-7 and MDA-MB-231 breast cancer cell lines and human embryonic kidney normal cell (HEK 293).    Materials and Methods: The ANTICP web server was used to predict anticancer peptides. The cytotoxic activity of peptides with high score (P26, P7) and low score (P19) was examined b...

Mitochondria are the power plants of cell and play key roles in activating apoptotic pathway cancer cells, which readily susceptible to cytotoxic reactive oxygen species temperature elevations. Herein, we develop a “nanomissile” that targets mitochondria enhance tumor treatment effects by facilitating mitochondrial dysfunction releasing cytochrome C activate cells under 650-nm laser irradiation...

Microwave Ablation 2,2′-Azobis(2-[2-imidazolin-2-yl]propane) dihydrochloride (AIPH)-loaded temperaturesensitive liposomes can be well accumulated in the tumor site after intravenous injection. In article 2202947 by Hu Peng, Zhengbao Zha, and co-workers, when is exposed to environment of microwave thermal ablation, release loaded AIPH decomposes produce cytotoxic free radicals. Tumor growth effe...