Objective(s):Helicobacter pylori infection occurs worldwide, but the prevalence of this infection varies greatly among different countries and population groups. The aim of this study was to determine the seroprevalence of anti-Helicobacter pylori and anti-cytotoxin-associated gene A (CagA) antibodies in asymptomatic healthy population in the center of Iran and to investigate the relation with ...

objective: helicobacter pylori is a major etiological agent in gastro-duodenal disorders, and has spread in the world. the prevalence of infection with h. pylori is more than 80% in some populations, but only 10% to 20% of them are infected with this organism. also infection with this pathogen is associated with peptic ulcer disease (pud), gastritis (g), duodenitis (du), and non-ulcer dyspepsi...

Abbreviations: Egr-1, early growth response gene-1; EGFR, epidermal growth factor receptor; ERK, extracellular-regulated kinases; MAP kinases, mitogen-activated protein kinases; PAI, pathogenicity island; cag, cytotoxin associated genes; PMA, Phorbol-12myristate-13-acetate; MOI, Multiplicity of infection; GAPDH, glyceraldehyde-3phosphate dehydrogenase; PCR, polymerase chain reaction; PBS, phosp...

Although Helicobacter pylori has a significant impact on the occurrence of severe clinical syndromes, its exact ways of transmission and origin have not been identified. According to the results of some previously published articles, foods with animal origins play a substantial role in the transmission of H. pylori to humans. The present investigation was carried out to study the vacuolating cy...

OBJECTIVE To detect the presence of virulence markers cytotoxin-associated (cagA) and vacuolating cytotoxin-associated (vacA) genes in gastric biopsy specimens of patients with gastroduodenal disorders. METHODS This study was conducted at the Department of Pathology, King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia between March 2008 and February 2009. A total of 118 gastric b...

background :   vaculating cytotoxic a ( vaca ) gene is one of the multiple helicobacter pylori genotypes that produce a cytotoxin protein (vaca).this gene is a major cause of chronic peptic ulcers and gastric cancer. the aim of this study was to determine the correlation between vaca gene with peptic ulcer disease (pud) and non-ulcer dyspepsia (nud). methods :    this was a case control study o...

INTRODUCTION There is an ongoing debate about the existence and effects of Helicobacter pylori (Hp) in adenotonsillar tissue. OBJECTIVE A clinical study was conducted to assess the existence of Hp in the adenoid and/or adenotonsillar tissues, which were surgically excised due to chronic adenotonsillitis. METHODS Phosphoglucosamine mutase gene for the detection of Hp and cytotoxin-associated...

Helicobacter (H.) suis has been associated with chronic gastritis and ulcers of the pars oesophagea in pigs, and with gastritis, peptic ulcer disease and gastric mucosa-associated lymphoid tissue lymphoma in humans. In order to obtain better insight into the genes involved in pathogenicity and in the specific adaptation to the gastric environment of H. suis, a genome analysis was performed of t...