abstractthe aim of the present study was to formulate poly (lactide-co-glycolide) (plga) nanoparticles loaded with 18-β-glycyrrhetinic acid (gla) with appropriate physicochemical properties and antimicrobial activity. gla loaded plga nanoparticles were prepared with different drug to polymer ratios, acetone contents and sonication times and the antibacterial activity of the developed nanopartic...

interleukin-12 (il-12) is a key cytokine involved in regulating the balance between th1 and th2 cells by promoting th1 response. a reduced capacity to produce this cytokine could lead to aberrant th2 development. on the same aspect significant impact of il-12 on invariant natural killer t (inkt) cells was reported. therefore, we examined the serum levels of il-12 and the absolute number of peri...

the current challenges in the management of esophageal cancer are to obtain a better understanding of underlying molecular alterations to provide new treatment options. we studied the p53 and bcl-2 protein expression in esophageal carcinomas to correlate molecular alterations with clinicopathological findings. tissue samples of 37 patients with advanced esophageal carcinoma were analyzed by imm...

background and purpose: future generalists require in depth exposure to primary care practice and the opportunity to work with successful generalist role models.changes in hospital practice, patient availability, increased student numbers and their expectations and a redefinition of expected learning outcomes are changing the emphasis of clinical teaching away from traditional inpatient setting...

in the long-term management of ulcerative colitis patients, repeat dosing maybe required. since 5-asa is largely absorbed from the upper intestine, selective delivery of drugs into the colon may be regarded as a better method of drug delivery with fewer side effects and a higher efficacy. the aim of this study was to prepare and evaluate a double coated multiparticulate system for 5-asa deliver...

in this work, modification of carbon paste electrode surface with poly (2, 5-dimethyl aniline) (p-2,5-dma) by using electrochemical polymerization was described. then, transition metal ions of ni(ii) were incorporated into the polymer film by two ways. at first way, the polymeric modified electrode was immersed in 0.2 m niso4 solutions and the second way was carried out by electrodeposition of ...

background and purpose: cervical cancer is the most prevalent cancer among women in the world. cervical cancer is no symptoms and can be treated if diagnosed in the first stage of the disease. the aim of this study was to survey the affecting factors of the pap smears test on perceptual factors, enabling and reinforcing (pen-3) model constructs in women. materials and methods: this study was a ...

the study of biochemical characteristics and metabolic activity of lactobacilli is necessary for selecting strains to be used as starter cultures for bread production. in this study, biochemical characteristics, acidification and probiotic properties of lactobacillus strains (lactobacillus plantarum, l. curvatus, l. paralimentarius) isolated from traditional sourdoughs were evaluated. all three...