BACKGROUND The development of a novel tuberculosis vaccine is a leading global health priority. SRL172, an inactivated, whole-cell mycobacterial vaccine, was safe, immunogenic and reduced the incidence of culture-confirmed tuberculosis in a phase III trial in HIV-infected and BCG immunized adults in Tanzania. Here we describe the immunogenicity and protective efficacy of DAR-901, a booster vacc...

In Tanzania, a large amount of domestic and industrial wastes are daily released to the aquatic environment without prior treatment. The demographic pressure resulting from the about 2.5 million people in the Dar es Salaam region (according to the 2002 National Census) is the major driver of amounts of waste released. Heavy metals such as arsenic (As), cadmium (Cd), cobalt (Co), chromium (Cr), ...

يتركز هذا البحث في تطبيق أحد طريقة تعليم اللغة العربية، وهي تحليل الأخطاء. هذه الطريقة فرع من فروع علم التطبيقي الدراسات اللغوية العربية. وكانت مستخدمة لمعرفة المشكلات الموجهة للداسين أثناء تعلم الإملاء المواد للطالبات برنامج الإعداد اللغوي بجامعة دار السلام كونتور التي واجب تعلمها خاصة لتنمية مهارة الكتابة. لذلك يهدف إلى تعريف الأخطاء، أهمية مادة الإملاء، ثم الأخطاء الإملاء. المنهج المستخدم من...

architecture has been always recognized as a framework which is influenced by social beliefs, traditions and interactions and furthermore affects individual soul and tendency. therefore it is impossible to analyze and consequently identify an architectural artifact if not accompanied by analysis of intellectual fundamentals of its contemporary society. the ensemble of sheikh safi al-din which i...

Previously, D2 dopamine receptors (D2 DARs) have been shown to undergo G-protein-coupled receptor kinase phosphorylation in an agonist-specific fashion. We have now investigated the ability of the second messenger-activated protein kinases, protein kinase A (PKA) and protein kinase C (PKC), to mediate phosphorylation and desensitization of the D2 DAR. HEK293T cells were transiently transfected ...

BACKGROUND Loss of dorsal acetabular rim (DAR) is a common sequela to canine hip dysplasia. The purpose of this study is to evaluate the effect of DAR loss on the initial stability of the cementless (BFX) acetabular cup. BFX cups were implanted into foam blocks reamed to resemble acetabulae with simulated 0, 25, 50, and 75% DAR loss. Models were tested in edge loading of the lateral surface of ...