background: protective effect of emblica against radiation and cadmium induced biochemical changes in mouse kidney has been studied. materials and methods: adult male mice were divided into seven groups: i (shamirradiated), ii (cadmium chloride), iii (irradiated with 2 gy gamma rays), iv (radiation and cadmium chloride), v (cadmium chloride and emblica), vi (radiation and emblica), vii (radiati...

background and aims: probiotics are defined as live microorganisms that are beneficial to human health. probiotics are commonly found in some foods such as dairy products or complementary tablets. a recent research shows that probiotics have a significant role in diabetes type 1 and 2 treatment. among the variety of lactic acid bacteria, lactobacillus strains are well known in probiotics for th...

in the present study, interactions between lead exposure with nitric oxide precursor (l-arginine) or nitric oxide synthase (nos) inhibitor (l-name) on naloxone-induced jumping and diarrhea in morphine-dependent mice were examined. chronic lead acetate (0.05%) exposure altered naloxone-induced jumping and diarrhea in mice. jumping was decreased after 7 days and was unchanged 14 and 28 days after...

introduction: some studies show magnesium has anticonvulsive effect in some animal models. despite of the availability of well-studied anticonvulsant drugs, this evaluation was not carried on new kind of magnesium supplement, magnesium oxide nanoparticles (nmgo). according to the interaction between magnesium and convulsion, this study was designed to evaluate the effect of nmgo on strychnine-i...

background: endometrial development has an important role in blastocyst adhesion and implantation. during ivf cycles, endometrial development is enhanced by progesterone. objective: the aim of this study was to compare ultrastructural and morphometrical characteristics of mice uterine endometrium in natural cycle with those in superovulated cycles received progesterone or sildenafil. materials ...

background: acrylamide (aa) is an important industrial chemical primarily. aa is also found in carbohydrate-rich foods that are prepared at high temperatures, such as french fries and potato chips. it is demonstrated that aa is a carcinogen and reproductive toxin and has ability to induce sperm damage. objective: the aim of this study was to observe the effects of aa on sperm parameters and eva...

background : breast cancer is a complicated disease and has various clinical manifestations and prognosis. the aim of this study is to make a breast cancer model suitable for basic, preclinical and clinical studies. materials and methods: five virgin bulb/c mice aged 6 weeks and spontaneous murine mammary adenocarcinoma cells (mmac) were used. after anesthesia induction, 1-3 million of mmacs we...

background thymus species are well known medicinal plants which the previous studies suggested the involvement of the opioid system in them. objectives this study aimed to investigate the effects of methanolic extract and essential oil of aerial parts of thymus daenensis (td), an endemic aromatic medicinal plant of iran, on morphine withdrawal syndrome in mice. materials and methods experiments...

background: carum carvi l . (caraway), known as black zeera in iran, has been indicated for the treatment of epilepsy in iranian folk medicine. this study evaluated whether the aqueous extract and essential oil of caraway seeds have anticonvulsant effects in mice. methods: the anticonvulsant effects of the aqueous extract (200, 400, 800, 1600, and 3200 mg/kg, i.p.) and essential oil (25, 50, 10...

objective: as the aqueous extract of capparis spinosa (cs) possess antidiabetic effect, he present study aims to reveal the possible  mechanism of action of cs in diabetic mice.materials and methods: both single and repeated oral administrations of aqueous extract of cs were performed in multi-low dose streptozotocin-induced (mlds) diabetic mice. euglycemic hyperinsulinemic clamp was used in as...