Effective activation of dendritic cells (DCs) toward T helper (Th)-1 cell polarization would improve DC-based antitumor immunotherapy, helping promote the development of immunotherapeutic vaccines based on T-cell immunity. To achieve this goal, it is essential to develop effective immune adjuvants that can induce powerful Th1 cell immune responses. The pathogenic organism Mycobacterium tubercul...

OBJECTIVE To test the applicability of different types of commercially available electrodes and electrode gels or pastes for recording of slow EEG potentials. METHODS Experiments were carried out on six types of reusable electrodes (silver, tin and gold cup electrodes, sintered silver-silver chloride (Ag|AgCl), platinum, stainless steel), six disposable Ag|AgCl electrode models, and nine gels...

BACKGROUND Recent reports indicate that dendritic cell (DC)-derived T-cell immunoglobulin and mucin domain molecule (TIM)-4 plays an important role in the initiation of T(H)2 polarization. This study aims to elucidate the mechanisms of peanut allergy mediated by microbial products and DCs and the relationship between peanut allergy and TIM4. METHODS Mouse bone marrow-derived DCs (BMDCs) were ...

This paper proposes a novel liquid crystal-filled, dual core photonic crystal fiber polarization beam splitter (LC-DC-PCF PBS) based on the coupled mode theory of DC-PCF. The birefringence odd and even modes, coupling lengths (CLs) X-polarization (X-pol) Y-polarization (Y-pol), corresponding length ratio (CLR) proposed LC-DC-PCF PBS filled without LC E7 with are compared. change rules CLs X-pol...

For battery-powered electronic products, one way to extend battery life is to use a versatile step-up/step-down DC-DC converter. A new versatile step-up/step-down switched-capacitor-based converter structure is proposed, and its efficiency is analyzed. In the step-down case, the efficiency is the same as, or even better than the efficiency of linear regulators. key words: DC-DC converter, switc...

Mild heat stress can modulate the activities of immune cells, including dendritic cells (DC) and theoretically, would constitute an innovative approach capable of enhancing the antitumor functions of DC. Therefore, we tested the effects of mild heat stress on the physiology and viability of human monocyte-derived DC, the major type of DC used in tumor immunotherapy trials. We first designed a h...

Primary acute myeloid leukemia cells can be induced to differentiate into dendritic cells (DC). In the presence of GM-CSF, TNF-alpha, and/or IL-4, leukemia-derived DC are obtained that display features of immature DC (i-DC). The aim of this study was to determine whether i-DC of leukemic origin could be further differentiated into mature DC (m-DC) and to evaluate the possibility that leukemic m...

OBJECTIVE Dendritic cells (DC) accumulate in atherosclerotic arteries where they can modulate atherogenesis. We investigated whether plasmin might alter the function of human DC. METHODS AND RESULTS Stimulation of monocyte-derived DC with plasmin elicited a time-dependent actin polymerization and chemotaxis comparable to that triggered by the standard chemoattractant formyl-methionyl-leucyl-p...

Despite the pivotal role of dendritic cells (DC) in shaping immunity, little is known about their functionality in type 1 diabetes. Moreover, due to the paucity of DC in vivo, functional studies have relied largely upon in vitro-expanded cells to elucidate type 1 diabetes-associated functional abnormalities. In this study, we provide a comprehensive analysis of the functional capabilities of in...