BACKGROUND Left ventricular diastolic dysfunction (DD) is common after myocardial infarction (MI) despite preservation of left ventricular ejection fraction, yet it remains unclear how or whether DD affects cardiac hemodynamics with stress. METHODS AND RESULTS Invasive hemodynamic exercise testing was performed in 46 patients with a recent MI and left ventricular ejection fraction >45% and in...

Darier disease (DD) is a rare dominantly inherited genodermatosis characterized by loss of intercellular adhesion (acantholysis) and abnormal keratinization. DD is often difficult to manage. Numerous treatments have reportedly been used for the treatment of DD, with limited success. Systemic retinoids are considered the drug of choice for treating DD. However, their use is limited by potential ...

OBJECTIVE The benefits of cochlear implantation for children with developmental delays (DD) often are unclear. We compared cognition, adaptive behavior, familial stress, and communication in children with and without DD. STUDY DESIGN Retrospective review. SETTING Two tertiary care pediatric hospitals. PATIENTS Two hundred four children who underwent cochlear implantation assessed before a...

Diastolic depolarization (DD) of atrial myocytes can lead to spontaneous action potentials (APs) and, potentially, atrial tachyarrhythmias. This study examined the hypotheses that 1) a slowly inactivating component of the Na(+) current (referred to as late I(Na)) may contribute to DD and initiate AP firing and that 2) blocking late I(Na) will reduce spontaneous and induced firing of APs by atri...

is the most fundamental example. Much like in the classical case of the Lebesgue di erentiation theorem, pointwise convergence almost everywhere of the inverse Fourier transform to f ∈ Lp (R) can be reduced to Lp bounds for the maximal operator C. Weak type L2 bounds were rst obtained by Lennart Carleson in 1966 [8], thus providing a surprising a rmative solution to the question of pointwise co...

One component in Additive Schwarz Method (ASM) Domain Decomposition (DD) preconditioners BPS89, SBG96] using inexact subdomain solvers Boe89, HLM91] consists in an operator extending the boundary data into the interior of each subdomain, i.e. a homogeneous extension with respect to the diierential operator given in that subdomain. This paper is concerned with the construction of cheap extension...

In this paper we present an overview of the field of distributed development of software systems and applications (DD). Based on an analysis of the published literature, we consider threats to communication, coordination and control in DD caused by Temporal Distance, Geographical Distance, and Socio-Cultural Distance. The analysis results in a more complete framework for reasoning in the DD dom...

Bovine digital dermatitis (DD) is the most important infectious disease associated with lameness in cattle worldwide. Since the disease was first described in 1974, a series of Treponema species concurrent with other microbes have been identified in DD lesions, suggesting a polymicrobial etiology. However, the pathogenesis of DD and the source of the causative microbes remain unclear. Here we c...