BACKGROUND Deep-brain stimulation (DBS) is an established treatment for medically refractory essential tremor (ET). This article reviews the current evidence supporting the efficacy and safety of DBS targets, including the ventral intermediate (VIM) nucleus and posterior subthalamic area (PSA) in treatment of ET. METHODS A structured PubMed search was performed through December 2012 with keyw...

As the population of patients treated with deep brain stimulation (DBS) grows and the patients age, more will require routine or emergent electrophysiologic tests. DBS artifact may render these uninterpretable, whereas stopping DBS may release symptoms that confound evaluation. The authors find that monopolar, but not bipolar, stimulation produces significant artifact during EKG, EEG, and polys...

Deep brain stimulation (DBS) of the basal ganglia can alleviate the motor symptoms of Parkinson's disease although the therapeutic mechanisms are unclear. We hypothesize that DBS relieves symptoms by minimizing pathologically disordered neuronal activity in the basal ganglia. In human participants with parkinsonism and clinically effective deep brain leads, regular (i.e., periodic) high-frequen...

Deep brain stimulation (DBS) can relieve dyskinesias effectively and safely. This modality is applied most commonly in the treatment of dyskinesias associated with levodopa therapy for Parkinson disease. The subthalamic nucleus (STN) and globus pallidus internus (GPi) are the most common surgical targets. Deep brain stimulation of the GP has a direct antidyskinetic effect, whereas relief of dys...

Abstract Deep brain stimulation (DBS) of the anterior limb internal capsule (ALIC) has shown promise as a therapy for refractory obsessive-compulsive disorder (OCD) and major depressive (MDD). DBS currently is ‘open-loop’ with parameters remaining fixed over time. In contrast, ‘closed-loop’ delivers only when biomarker target symptom state indicates it needed. One challenge to development close...

Recent developments in Deep Brain Stimulation (DBS) and computer technology have resulted in dramatically new and effective surgical treatments for Parkinson's disease and other movement disorders. From the DBS, by research, the concept has evolved to Closed-Loop neuroStimulation (CLnS) which is the brain target point electric stimulation linked to the patient's body and brain response. One del...

Abstract Introduction: Adaptive deep brain stimulation (DBS) aims at improving DBS therapy by adjusting amplitude in response to biomarkers tracked real-time. In Parkinson’s Disease (PD), one type of aDBS exploits fast fluctuations beta power (beta bursts) local field potentials. With this method, is applied as soon bursts a given magnitude and duration are detected. However, it unknown how per...

BACKGROUND Deep brain stimulation (DBS) has been shown to be effective for Parkinson's disease, essential tremor, and primary dystonia. However, mixed results have been reported in Huntington's disease (HD). CASE REPORT A single case of HD DBS was identified from the University of Florida DBS Brain Tissue Network. The clinical presentation, evolution, surgical planning, DBS parameters, clinic...

Deep-brain stimulation (DBS) is a clinical intervention that has provided remarkable therapeutic benefits for otherwise treatment-resistant movement and affective disorders. The resulting direct causal manipulation of both local and distributed brain networks is not only clinically helpful but can also help to provide novel fundamental insights into brain function. In particular, DBS can be use...

Applying high-frequency stimulation (HFS) to deep brain structure, known as deep brain stimulation (DBS), has now been recognized an effective therapeutic option for a wide range of neurological and psychiatric disorders. DBS targeting the basal ganglia thalamo-cortical loop, especially the internal segment of the globus pallidus (GPi), subthalamic nucleus (STN) and thalamus, has been widely em...