In the past few years there have been significant advances in the identification of putative stem cells also referred to as "mesenchymal stem cells" (MSC) in dental tissues including the dental pulp. It is thought that MSC in dental pulp share certain similarities with MSC isolated from other tissues. However, cells in dental pulp are still poorly characterized. This study focused on the charac...

introduction: accurate diagnosis of dental pulp conditions plays a key role in selection of an appropriate treatment including conservative vital pulp therapy (treatable pulp) or root canal treatment (untreatable pulp). the purpose of this study was to assess the accuracy of sensibility tests and the correlation of pulp response to sensibility tests with histologic pulp condition . material and...

BACKGROUND There is increasing evidence that peripheral glutamate signaling mechanism is involved in the nociceptive transmission during pathological conditions. However, little is known about the glutamate signaling mechanism and related specific type of vesicular glutamate transporter (VGLUT) in the dental pulp following inflammation. To address this issue, we investigated expression and prot...

The ultimate goal of endodontics therapy is the regeneration of tooth supporting tissues. This case study evaluated whether the transplantation of autologous dental pulp stem cells with chitosan scaffold into pulpless root canals could mediate pulp regeneration in human mature teeth. The dental pulp stem cells isolated from the patient`s pulp tissue. The cells were then seeded onto a chitosan s...

Background: Although cleft lip and palate deformities are the most common facial birth defect (1 in 600 births), only a few genes, IRF6 (associated with Van der Wounde) and transforming growth factor-beta 3 (TGFB3), have been implicated in the disease. Dental pulp stem cells (DPSC) have similar developmental process with neural crest migration into core mesoderm and ectoderm and may be used to ...

Introduction Quantification of carious lesions and measurement of the distance to the pulp is an important task in conservative dentistry. This information can improve identification of cases with the potential for maintaining pulp vitality and monitor treatment success of indirect pulp capping. In the procedure of indirect pulp capping the nearly exposed pulp is covered with a chemical (usuall...

Inflammatory response in the dental pulp can alter the collagen matrix formation by dental pulp stem cells and lead to a delay or poor healing of the pulp. This inflammatory response is mediated by cytokines, including interleukin-1β and tumor necrosis factor-α. In this study, it is hypothesized that suppressing the actions of these inflammatory cytokines by knocking down the activity of transc...

In 6 dogs, experiments were performed to determine the tissue reaction of the dental pulp at the 7, 30 and 60 days after direct contact of the pulp with the obturation material through a microcommunication orifice with diameter up to 1 mm, formed in the fundic part of an experimental cavity. Capping of 36 mandibular premolars with traumatically exposed pulp was carried out. On the exposed pulp,...

Dental caries is one of the most widely prevalent infectious diseases in the world. It affects more than half of the world's population. The current treatment for necrotic dental pulp tissue arising from dental caries is root canal therapy. This treatment results in loss of tooth sensitivity and vitality making it prone for secondary infections. Over the past decade, several tissue-engineering ...