objective: to compare side effects between users of two kinds of injectable contraceptives (depo-medroxy progesterone acetate and cyclofem). materials and methods: this cross-sectional descriptive study included 250 women, aged 18-40 years, using depo-medroxy progesterone acetate (dmpa) or cyclofem. the volunteers were examined six months after using contraceptive, and they were asked about fol...

In the generally accepted schemes for the biosynthesis of adrenal cortical steroids (l-3), progesterone* is represented as the branch point in the formation of 17-hydroxycorticosteroids (Reactions D and F, Fig. l), on the one hand, and the 17-deoxycorticosteroids (Reaction E, Fig. l), on the other. Savard et al. (4) found that incubation of slices of an interstitial cell tumor of the testis wit...

The adverse outcomes seen in the Women's Health Initiative (WHI) 1 were mainly due to an over-dosage of hormones in a relatively elderly population. However, fundamental differences exist between conjugated equine estrogens and 17 beta estradiol and between medroxyprogesterone acetate and natural progesterone. It is likely that these differences also contributed to the adverse outcomes in WHI, ...

Sex steroid hormone progesterone is known to have profound effects on the growth and differentiation of the normal mammary gland and malignant breast epithelial cells. In vitro progesterone and synthetic progesterone-like compounds (progestins) inhibit breast cancer cell growth. Medroxyprogesterone acetate (MPA) is a synthetic hormone widely used in the adjuvant treatment of advanced breast can...

INTRODUCTION In the U.S., it is estimated that onehalf of the six million pregnancies that occur each year are unplanned or un expected.1 Despite the widespread of use of various contraceptive methods, including hormonal contraceptive tablets and condoms, these methods remain imperfect. Inadequate contraceptive use or failure of a contraceptive method, in addition to unprotected sexual intercou...

1. The effect of progesterone on renal haemodynamics and intrarenal sodium handing was evaluated in thirteen normal men on a constant diet. Clearances were measured during maximal water diuresis and again 4-7 days later, this time 3 h after progesterone was given intramuscularly. Seven additional studies were performed 3 days after progesterone administration. Another four tests were performed ...

BACKGROUND The effects of progestogens on endothelial physiology are poorly studied. Prostacyclin is a potent vasodilator synthesized by two isoforms of cyclooxygenase (COX) in endothelium. We examined the effects of two clinically used progestogens, progesterone and medroxyprogesterone acetate (MPA), on prostacyclin production by cultured human umbilical vein endothelial cells (HUVEC) and the ...

Two experiments were conducted over 3 yr to determine pregnancy rates in beef heifers after a timed AI in response to the 7-11 Synch protocol. In Exp. 1, 179 heifers were either fed melengestrol acetate (MGA; 7-11 Synch) or given an intravaginal progesterone (P4)-releasing insert [controlled intravaginal drug releasing device (CIDR); 7-11 CIDR] for 7 d. Prostaglandin F2αwas administered on the ...