22 23 Implementation of highway-rail grade crossing warning systems, educational programs and 24 research on crossings have all contributed to a steady reduction in the risk to highway users of 25 grade crossings over the past several decades. Much less attention has been given to 26 understanding the effect of grade crossings on train safety and risk. Collisions at highway-rail 27 grade crossi...

The article puts forward a hypothesis according to which the violation of nominal setting wheel pairs in railway rolling stock carts is main reason for increase guiding forces flange contacts wheels freight cars with rails. Increased loads are cause number other negative phenomena: increased intensity wear (undercutting) flange, side surfaces rail heads, decrease coefficient stability wagons fr...

It is not surprising that the complex metabolic machinery of the gut microbiome has accidental, or directed, ability to alter our medicines and influence their efficacy. What is not known is the extent to which this has contributed to drug failures or contraindications, or to the derailment of clinical trials. Some studies are unraveling the mechanisms by which the microbiota alter specific dru...

A large amount of data supports the view that PTEN is a bona fide tumor suppressor gene. However, recent evidence suggests that derailment of cellular localization and expression levels of functional nonmutated PTEN is a determining force in inducing abnormal cellular and tissue outcomes. As the cellular mechanisms that regulate normal PTEN enzymatic activity resolve, it is evident that deregul...