The peptide group between residues B24 and B25 of insulin was replaced by an ester bond. This modification only in the backbone was meant to eliminate a structurally important H-bond between the amide proton of B25 and the carbonyl oxygen of A19, and consequently to enhance detachment of the C-terminal B-chain from the body of the molecule, exposing the underlying A-chain. According to a model ...

The object management architecture (OMA) has been recognized as a de facto standard in the development of object services in a distributed computing environment. In a distributed system, the provision for failure-recovery is always a vital design issue. However, the fault-tolerant service has not been extensively considered in the current OMA framework, despite the fact that an increasing numbe...

The Bayesian network (BN) is a new intelligent evaluation technology, which has become one of the effective methods to solve uncertainty problems and deal with asymmetric information. However, its application limited in case complex indicator systems interrelated variables. To these problems, an improved BN model based on game theory proposed. First, IHORAFA attribute reduction algorithm used o...

Despite prolific research on IT business value, this stream of research still encounters considerable limitations such as inconsistent findings of the direct link between IT and firm profitability and the demonstration of the indirect relationship between IT and specific aspects of firm value without explicitly considering network environments. To overcome the limitations caused by utilizing th...

Despite the need for sustaining competitive advantage, scholars and practitioners struggle when deciding which organizational capabilities they should develop to which extent. Today, inconsistent recommendations bear the risk of misallocating corporate funds. Despite recent advances, further research needs to be conducted with respect to how uncertainty can be considered in capability developme...