easily degradating and various isomeric forms of rapamycin (sirolimus) face the determination of this compound to many challenges. in this study, we developed and validated the isocratic reversed phase high performance liquid chromatographic (rp-hplc) method for rapamycin. separation was performed on a c8 column (mz, 15 × 4.6 mm, 5 µm particle size) using methanol:water (80:20 v/v) as the mobil...

a gradient reversed-phase high performance liquid chromatography (hplc) method was developed for the assay of cetrorelix acetate, a synthetic decapeptide with gonadotropin-releasing hormone (gnrh) antagonistic activity used in infertility treatment. the hplc method, which is used to determine cetrorelix in bulk and pharmaceutical dosage forms, was validated per ich guidelines. the chromatograph...

quick identification of vibrio cholerae in epidemics is   important, on the other hand; conventional methods are time-consuming and   costly. the aim of this study was to develop a rapid, inexpensive and high   sensitivity method for quick identification of vibrio cholerae . for   this purpose we designed a pcr detection based on magnetic nanoparticles for   identification of bacterial dna by p...

conclusions both task-related and resting fmri techniques have the potential to detect early brain dysfunction related to ad. however, the use of fmri in ad populations thus far has been limited to a relatively small number of research groups. results bold fmri is considered to reflect the joined synaptic activity of neurons through mri signal changes because of alterations in blood flow, blood...

from the winter 2002 to spring 2006, 126 moribund rainbow trout with clinical signs of external body haemorrhages around and within the oral cavity were sampled from 10 rainbow trout farms situated in the northwest and west of fars province, iran and examined for the detection and identification of yersinia ruckeri, the causative agent of enteric redmouth disease. fish kidneys were cultured ase...

background: canine parvovirus (cpv) infection is one ofthe most common causes of infectious gastroenteritis in dogs andis a highly contagious, often fatal disease. the original virus(cpv type 2) has had some mutations since its emergence andnew variants (cpv-2a, 2b and 2c) have been reported from manycountries all around the world. early diagnosis and treatment canprofoundly affect the disease ...

no report has been published on the economical losses associated with errors in oestrus detection in cows under iranian intensive dairy management. the following study was carried out to determine the accuracy of oestrus detection by farmers using artificial insemination in shiraz dairy farms. milk samples were collected from 179 holstein milking cows at the time of artificial insemination. mil...

in this paper a new algorithm is presented for coherent radar detection of targets, when distribution of the interference (clutter and noise) is non-gaussian. the neyman-pearson criterion is used for optimal detection and several successive received samples from a radar range cell are used for detection in the same cell. on the basis of recent empirical evidences, the interference distribution ...

a critical protection requirement for grid connected distributed generators (dg) is anti-islanding protection. in this paper, a new islanding detection method for any possible network loading is proposed based on utilizing and combining various system parameter indices. in order to secure the detection of islanding, eight intentional disturbances are imposed to the system under study in which t...

cell free dna (cfdna) is a genetic biomarker that is present in serum or plasma in high concentration in many types of cancer. identification of circu-lating cancer related dna molecules in serum or plasma is a non-invasive tool for early diagnosis and prognosis in many cancer patients. for this review, study selection and data extraction were performed by the authors. detection of point mutati...